“5+2”间歇性断食模式对体重超标患者的临床效果研究  

Clinical Effects of"5+2"Intermittent Fasting on Overweight Patients

作　　者：孙桂丽[1] 邓志杰 黄丽婵 卢连 黄晓铃 SUN Guili;DENG Zhijie;HUANG Lichan;LU Lian;HUANG Xiaoling(Department of Clinical Nutrition,Nanning Second People′s Hospital,Nanning 530031,China)

机构地区：[1]南宁市第二人民医院临床营养科,南宁530031

出　　处：《医学综述》2021年第3期598-603,共6页Medical Recapitulate

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180585)。

摘　　要：目的分析"5+2"间歇性断食模式对体重超标患者的临床效果。方法选取2018年9月至2019年3月在南宁市第二人民医院临床营养科就诊的68例体重超标患者作为研究对象,实施"5+2"间歇性断食干预12周,对比干预前后体格测量指标[体重、体质指数(BMI)、腰围等]、体成分分析指标(身体总水分、身体总蛋白、身体总脂肪、体脂率等)、实验室检查指标[红细胞计数、血红蛋白、丙氨酸转氨酶、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖等]以及肝脏脂肪沉积的变化。结果最终56例患者完成本研究。经"5+2"间歇性断食干预后,体重超标患者体重、BMI、腰围、臀围、腰臀比、身体总水分、身体总蛋白、身体总脂肪、体脂率、内脏脂肪面积、去脂体重、骨骼肌重量、基础代谢率和全身相位角,血清总胆固醇、三酰甘油、LDL-C、空腹血糖、空腹胰岛素水平和胰岛素抵抗指数均低于干预前(P<0.05或P<0.01);HDL-C、25-羟维生素D2、25-羟维生素D3水平高于干预前[1.26(1.12,1.56)mmol/L比1.00(0.87,1.19)mmol/L,62.60(54.40,74.30)IU/L比51.60(42.60,63.40)IU/L,1137.40(910.40,1322.30)IU/L比946.60(808.50,1112.10)IU/L](P<0.01)。结论"5+2"间歇性断食模式可有效降低体重超标患者的体重和体脂率,改善糖脂代谢和非酒精性脂肪肝,对肝、肾功能无不良影响,具有良好的减重效果。Objective To explore the clinical effects of"5+2"intermittent fasting on overweight patients.Methods68 overweight patients in the Department of Clinical Nutrition of Nanning Second People’s Hospital from Sep.2018 to Mar.2019 were included,and the"5+2"intermittent fasting intervention was implemented for 12 weeks.The physical examination indexes[weight,body mass index(BMI),waist circumference,etc.],body composition analysis indexes(total body water,total protein,body fat mass,body fat rate,etc.),laboratory examination indexes[red blood cell count,hemoglobin,alanine aminotransferase,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose,etc.]and liver fat deposition changes were compared before and after the intervention.Results Finally,56 patients completed the study.After the"5+2"intermittent fasting intervention,the body weight,BMI,waist circumference,hip circumference,waist hip ratio,total body moisture,total body protein,total body fat,body fat rate,visceral fat area,fat free weight,skeletal muscle weight,basal metabolic rate and body phase angle,serum total cholesterol,triglyceride,LDL-C,fasting blood glucose,fasting insulin and insulin resistance index were all lower than those before the intervention(P<0.05 or P<0.01).The levels of HDL-C,25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 were higher than those before the intervention[1.26(1.12,1.56)mmol/L vs 1.00(0.87,1.19)mmol/L,62.60(54.40,74.30)IU/L vs 51.60(42.60,63.40)IU/L,1137.40(910.40,1322.30)IU/L vs 946.60(808.50,1112.10)IU/L](P<0.01).Conclusion"5+2"intermittent fasting mode can effectively reduce the body weight and body fat percentage of overweight patients,improve glycolipid metabolism and nonalcoholic fatty liver,with no adverse effects on liver and kidney function,presenting good weight loss effect.

关 键 词：体重超标 “5+2”间歇性断食 糖脂代谢 非酒精性脂肪肝 

分 类 号：R589[医药卫生—内分泌]