SNP在蚊虫种群遗传和蚊媒病控制中应用  

Application of single nucleotide polymorphism in mosquito population genetics and mosquito-borne disease control

作　　者：魏勇 王佳甜 郑学礼 WEI Yong;WANG Jia-tian;ZHENG Xue-li(Department of Pathogen Biology,School of Public Health,Southern Medical University,Guangzhou,Guangdong Province 510515,China)

机构地区：[1]南方医科大学公共卫生学院病原生物学系,广东广州510515

出　　处：《中国公共卫生》2021年第2期366-370,共5页Chinese Journal of Public Health

基　　金：国家自然科学基金(31630011);广东省自然科学基金(2017A030313625);广州市科技计划项目(201804020084)。

摘　　要：随着蚊虫在全球的大量扩散,以往较为局限的蚊媒疾病变得越来越普遍。登革热、基孔肯雅热、日本脑炎、西尼罗病毒病、黄热病和寨卡等是由蚊虫传播的几种常见和新兴的病毒性疾病。当地的蚊种及种群遗传特征对当地蚊媒疾病的暴发流行有着潜在的影响,所以蚊种鉴定和种群遗传研究在疾病控制方面显得尤为重要。单核苷酸多态性(SNP)标记是第三代遗传标记物,因其具有广泛分布性、遗传稳定性、易规模化检测等特点,成为目前遗传标记研究最多、最有前景的新一代DNA分子标记物。With the spread of mosquitoes around the world,mosquito-borne diseases used to be relatively confined in the past have become more and more common.Dengue fever,Chikungunya fever,Japanese encephalitis,West Nile virus disease,yellow fever,and Zika virus infection are several common and emerging viral diseases transmitted by mosquitoes.The local mosquito species and population genetic characteristics have a potential impact on the outbreak of local mosquitoborne diseases,so mosquito identification and population genetic research are particularly important in prevention and control of the diseases.Single nucleotide polymorphism(SNP)markers are the third generation genetic markers.Because of their characteristics of wide distribution,genetic stability and easy detection on a large scale,they have become the new generation DNA markers having been studied by most researches and have become the most promising molecular markers.

关 键 词：蚊虫 单核苷酸多态性(SNP) 种群遗传 蚊媒病控制 

分 类 号：R183.5[医药卫生—流行病学]