新冠肺炎药物盐酸阿比多尔的结构分析和稳定性考察  

Structural Analysis and Stability of Arbidol Hydrochloride,a Treatment Drug for COVID-19

作　　者：马雨璇 王娜[1] 王冰[1] 李钢[1] Ma Yuxuan;Wang Na;Wang Bing;Li Gang(School of Food Science and Pharmaceutical Engineering,Test&Analysis Center,Nanjing Normal University,Jiangsu Nanjing 210023)

机构地区：[1]南京师范大学食品与制药工程学院分析测试中心,江苏南京210023

出　　处：《化工时刊》2020年第12期1-6,共6页Chemical Industry Times

基　　金：江苏省大型科学仪器设备共享服务平台资助(BZ201403)。

摘　　要：本文利用多种现代分析手段对新型冠状病毒肺炎的推荐用药盐酸阿比多尔进行了结构分析,结果表明:质谱分析(MS)测得样品分子量为477.9,傅里叶变换红外光谱(FTIR)分析出样品骨架苯并吡咯及主要官能团与盐酸阿比多尔化学结构一致;热分析(DSC和TGA)测得盐酸阿比多尔熔点为154.06℃,在90.02℃和188.51℃发生两步失重分解;X-射线粉末衍射(PXRD)测得其八条特征峰2θ分别为4.80°、7.63°、9.29°、11.74°、19.09°、21.14°、22.98°、28.81°;扫描电子显微镜(SEM)观察到盐酸阿比多尔呈长条状。此外,高湿、高温、研磨实验表明,盐酸阿比多尔在高湿和高温环境下晶型稳定,研磨会减小晶型的择优取向,影响衍射峰的强度,随着研磨时间的增加盐酸阿比多尔由结晶态向非晶态转化。In this paper,a variety of modern analytical methods were used to analyze the structure and morphology of Abidor hydrochloride a recommended drug for COVID-19.The results are as follows,the molecular weight of the sample was 477.9 measured by mass spectrometry(MS),and the skeleton of the sample and its main functional groups were analyzed by fourier transform infrared spectroscopy(FTIR).The results of FTIR were consistent with the chemical structure of Abidor hydrochloride.The DSC thermogram of it showed a desolvation peak starting at 154.06℃.The TGA curve showed that two-step weight-loss decomposition occurred at 90.02℃and 188.51℃.The PXRD patterns of it indicated peaks at 2θ=4.80°,7.63°,9.29°,11.74°,19.09°,21.14°,22.98°,28.81°.It is seams that a few unique peaks and can be used for the identification.The SEM examination indicates that the morphological of it possess a long strip.In addition,the experiments of high humidity,high temperature and grinding showed that the crystal shape of Abidor hydrochloride was stable under high humidity and high temperature,and grinding would reduce the preferred orientation of the crystal shape and affect the strength of the diffraction peak.With the increase of grinding time,Abidor hydrochloride transformed from crystal state to amorphous state.

关 键 词：盐酸阿比多尔 结构分析 稳定性分析 X射线粉末衍射 

分 类 号：TG1[金属学及工艺—金属学]