Elabela-Apelin-APJ系统在血管重构稳态与血管疾病中的调控作用及相关药物研发进展  

The Regulatory Role of Elabela-Apelin-APJ System in Vascular Remodeling Homeostasis and Vascular Diseases and the Development of Related Drugs

作　　者：宋佳玮 陈临溪 钟久昌 SONG Jiawei;CHEN Linxi;ZHONG Jiuchang(Department of Cardiology,Beijing Chaoyang Hospital Affliated to Capital Medical University,Beijing 100020,China;Beijing Key Laboratory of Hypertension,Beijing 100020,China;Department of Pharmacology,School of Pharmacy,University of South China,Hengyang 421001,China)

机构地区：[1]首都医科大学附属北京朝阳医院心脏中心,北京100020 [2]北京市高血压重点实验室,北京100020 [3]南华大学药学院药理学教研室,湖南衡阳421001

出　　处：《药学进展》2020年第12期894-905,共12页Progress in Pharmaceutical Sciences

基　　金：国家重大研究计划资助项目(No.91849111);国家自然科学基金项目(No.81770253,No.81370362,No.81973326)。

摘　　要：Apelin受体(APJ)是一种G蛋白偶联受体,其内源性配体包括Elabela(ELA)和Apelin,在血管重构稳态和损伤修复中发挥重要作用。ELA-Apelin-APJ系统参与血管的生成、分化和纤维化,以及细胞凋亡、炎症反应、氧化应激和血压调控,其活性和表达异常参与动脉粥样硬化、高血压、肺动脉高压、脑卒中等血管疾病的发病过程。概述ELA-Apelin-APJ系统在血管重构稳态中的调控作用及其作为潜在药物靶点的研究新进展,以期为血管研究提供参考。Apelin receptor(APJ)is a G protein-coupled receptor and its endogenous ligands contain Elabela(ELA)and Apelin,which play important roles in vascular remodeling homeostasis and damage repair.ELA-Apelin-APJ system participates in the regulation of angiogenesis,differentiation and vascular fibrosis,as well as apoptosis,inflammation,oxidative stress and blood pressure levels,whose abnormal activity and expression are involved in the pathogenesis of vascular diseases such as atherosclerosis,hypertension,pulmonary hypertension and stroke.In this article,the regulatory roles of ELA-Apelin-APJ system in vascular remodeling homeostasis and its progress in research as potential drug targets are discussed,so as to provide reference for related vascular researches.

关 键 词：Elabela APELIN Apelin受体 血管疾病 血管重构 

分 类 号：R541.4[医药卫生—心血管疾病]