巨大动脉导管未闭治疗研究进展  

Treatment of Large Patent Ductus Arteriosus

作　　者：杨鹏辉 李谧[1] YANG Penghui;LI Mi(Department of Cardiology,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院心血管内科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆400014

出　　处：《心血管病学进展》2021年第1期68-71,85,共5页Advances in Cardiovascular Diseases

基　　金：重庆市卫生健康委医学科研计划重点项目(2016ZDxm018)。

摘　　要：动脉导管未闭是最常见的先天性心脏病之一,男女比例约1∶2。由于缺乏认识和延迟诊断等原因,巨大动脉导管未闭患者仍然多见。巨大动脉导管未闭分流可明显降低全身血压,减少流向全身器官的血流量,增加肺血流量和肺血管压力并降低肺顺应性,最终导致不可逆转的肺动脉高压,危及生命。目前关于巨大动脉导管未闭的诊断标准和治疗方法尚无统一共识,为了帮助临床医生了解相关的新进展,现将概述药物、外科手术与介入治疗在巨大动脉导管未闭中的应用。Patent ductus arteriosus(PDA)is one of the most common congenital heart diseases,and the ratio of male to female is about 1:2.Due to paucity of awareness and delay in diagnosis,patients with large PDA are still common.Large PDA shunt can decrease systemic blood pressure,reduce blood flow to systemic organs,increase pulmonary blood pressure and flow,and decrease lung compliance,ultimately leading to irreversible pulmonary arterial hypertension,which is life-threatening.At present,there is no consensus on the diagnostic criteria and treatment of large PDA.To help clinicians keep pace with the related research,this article provides an overview of the application of drug therapy,surgery and interventional therapy in large PDA.

关 键 词：巨大动脉导管未闭 药物治疗 外科手术 经导管封堵 

分 类 号：R541.1[医药卫生—心血管疾病]