降脂治疗中LDL-C水平目标值的探讨  

Discussion of target value of LDL-C level in lipid-lowering therapy

作　　者：何璐 王曦[1] HE Lu;WANG Xi(Department of Cardiology,First Affiliated Hospital of Chongqing Medical University,Chongqing,400000,China)

机构地区：[1]重庆医科大学附属第一医院心内科,重庆400000

出　　处：《心血管康复医学杂志》2021年第1期95-98,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：重庆市基础研究与前沿探索项目(重庆市自然科学基金)(cstc2018jcyjAX0058)。

摘　　要：血脂异常是动脉粥样硬化心血管疾病(ASCVD)的独立危险因素,降低低密度脂蛋白-胆固醇(LDL-C)水平,可显著降低ASCVD的发病率,但LDL-C的目标值应该是多少仍有争议。大多数研究证实,他汀类使LDL-C水平下降到调脂指南现有标准以下能使患者进一步受益,且降低至30mg/dl是安全的。因此,提倡在临床实践中,将LDL-C水平降低到现有指南推荐的水平以下。Dyslipidemia is an independent risk factor for atherosclerotic cardiovascular disease(ASCVD).Lowering level of low density lipoprotein-cholesterol(LDL-C)can significantly reduce morbidity of ASCVD,but the target value of LDL-C is still controversial.Most studies have confirmed that statins lower LDL-C level below the current standards of guidelines,which can further benefit patients.And it′s safe to reduce LDL-C to 30mg/dl.Therefore,it is recommended to reduce LDL-C level to below the recommended level of existing guidelines in clinical practice.

关 键 词：动脉粥样硬化 血脂异常 脂蛋白类 LDL 

分 类 号：R543.5[医药卫生—心血管疾病]