Ⅱ型固有淋巴细胞对T细胞分化的影响及其在免疫性疾病中的作用  

Effect of type 2 innate lymphoid cells on T cells and its role in immunity diseases

作　　者：吴瑶 蒋丽娜[2] 祝筱梅[1] 姚咏明[1] Wu Yao;Jiang Li-Na;Zhu Xiao-Mei;Yao Yong-Ming(Medical Innovation and Research Division,the Chinese PLA General Hospital,Beijing 100048,China;Medical Laboratory College of Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]解放军总医院医学创新研究部,北京100048 [2]河北北方学院医学检验学院,河北张家口075000

出　　处：《解放军医学杂志》2021年第1期71-75,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81730057);国家重点基础研究发展计划(2017YFC1103302)。

摘　　要：Ⅱ型固有淋巴细胞(ILC2)是新近发现的一种与T淋巴细胞密切相关的重要固有免疫细胞,对T淋巴细胞具有显著调控作用。大量研究证实,ILC2可有效诱导CD4+ T细胞向辅助性T细胞(Th)2亚型特异性分化,从而参与调节机体免疫平衡过程。该文就ILC2对于Th2特异性分化的影响及其在免疫性疾病中的作用进行综述。Type Ⅱ innate lymphoid cell (ILC2),a newly discovered important type of inherent immune cells closely related to T lymphocytes,has a significant regulatory impact on T lymphocytes.Many studies have demonstrated that ILC2 can effectively induce the differentiation of CD4~+ T cells to helper T cell (Th)2,thereby contributing to the modulation of host immune homeostasis.In the present paper,we would like to review the update of possible effects of ILC2 on Th2 differentiation and its role in immunity diseases.

关 键 词：Ⅱ型固有淋巴细胞 辅助性T细胞2 免疫反应 

分 类 号：R392[医药卫生—免疫学]