LC3和lamins在细胞核自噬中的研究进展  

Progress of LC3 and Lamins in Nucleophagy

作　　者：韩晓梦 李冠武 HAN Xiaomeng;LI Guanwu(Department of Biochemistry and Molecular Biology,Shantou University Medical College,Open Laboratory for Molecular Biology of Cancer,Shantou 515041,Guangdong,China)

机构地区：[1]汕头大学医学院生物化学与分子生物学教研室,肿瘤分子生物学开放实验室,广东汕头515041

出　　处：《汕头大学学报（自然科学版）》2021年第1期62-68,共7页Journal of Shantou University：Natural Science Edition

基　　金：广东省基础与应用基础研究基金资助项目(2019A1515010962)。

摘　　要：自噬是细胞内的重要生理机制之一,对细胞来说自噬是一把双刃剑,它曾一度被认为是机体的保护机制,但随着研究的深入,学者发现自噬也可促进肿瘤的生长.由于细胞核在真核生物中的重要性,相关自噬蛋白在核中的大量分布,核自噬在多种疾病的发生发展中起着非常重要的作用.为了全面了解疾病与自噬的关系,人们开始了核自噬方面的探索.本文对近年来核自噬的研究进展进行文献综述,总结了其研究历史和里程碑式的发现,为核自噬的研究提供了新的思路.Autophagy is one of the important physiological mechanisms in cells.For cells,autophagy is a double-edged sword.It was once considered as a protective mechanism of the body,but with the deepening of research.Scholars found that autophagy can also promote the growth of tumors.Due to the importance of the nucleus in eukaryotes and the large distribution of related autophagy proteins in the nucleus,nuclear autophagy plays a very important role in the occurrence and development of a variety of diseases.In order to fully understand the relationship between disease and autophagy,nuclear autophagy is explored.In this paper,the research progress of nuclear autophagy is reviewed.The research history and landmark findings is summarized and new ideas for the research of nuclear autophagy are provided.

关 键 词：核自噬 微自噬 核纤层 LC3 LAMINS 

分 类 号：R34[医药卫生—基础医学]