聚乙烯吡咯烷酮用于药物递送载体材料的研究进展  

Research on polyvinylpyrrolidone as drug delivery carrier materials

作　　者：詹世平[1,2] 刘思啸 王景昌 赵启成[1,2] 王卫京 ZHAN Shiping;LIU Sixiao;WANG Jingchang;ZHAO Qicheng;WANG Weijing(College of Environmental & Chemical Engineering, Dalian University, Dalian 116622, China;Chemical and Environmental Protection Engineering Research Technology Center, Dalian 116622, China)

机构地区：[1]大连大学环境与化学工程学院,辽宁大连116622 [2]辽宁省化工环保工程技术研究中心,辽宁大连116622

出　　处：《功能材料》2021年第1期1033-1038,共6页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(21676038)。

摘　　要：高分子药物递送载体材料具有良好的生物相容性和生物可降解性,可以有选择性的释放药物,以提高药物利用率和降低药物的副作用,因此,高分子药物递送载体材料已成为当前的研究热点。聚乙烯吡咯烷酮(PVP)是一种绿色的高分子材料,具有优异的溶解性和低毒性,在医用材料领域具有广泛的应用。主要介绍了高分子药物递送载体材料的基本特性,并对聚乙烯吡咯烷酮的特性、合成、改性以及应用进行了较详细的论述,最后对其发展和应用前景进行了展望。Polymeric as the drug delivery carrier materials have a good biocompatibility and biodegradability,and can selectively release drugs,so the utilization ratio and the side effects of the drug can be improved.Therefore,the polymer as the drug delivery carrier materials is a focus of the current research.Polyvinylpyrrolidone is a green polymer material with the excellent solubility and low toxicity,and has been widely used in the field of medical materials.The basic characteristics of the drug delivery carrier materials were introduced,and the property,synthetic process,modification and application of polyvinylpyrrolidone were mainly discussed.The application prospect and development trend of polyvinylpyrrolidone as the anticancer drug carrier materials were also forecasted.

关 键 词：药物递送载体 聚乙烯吡咯烷酮 靶向性 响应性 

分 类 号：TB34[一般工业技术—材料科学与工程]