急性脊髓损伤的治疗进展  

Progress in treatment of acute spinal cord injury

作　　者：施玉博 余铃[1] 郭卫春[1] SHI Yubo;YU Ling;GUO Weichun(Department of Orthopedics,Renmin Hospital of Wuhan University,Hubei Province,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院脊柱外科,湖北武汉430060

出　　处：《中国医药导报》2021年第1期36-39,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81502575);湖北省武汉市中青年医学骨干人才项目(〔2019〕87号)。

摘　　要：急性脊髓损伤会导致脊髓损伤平面以下出现感觉和运动功能障碍,严重影响患者的生活质量。近年来,随着对脊髓损伤病理机制研究的不断深入,急性脊髓损伤的治疗取得了一定的进展。手术治疗能够重建脊柱稳定性、解除脊髓压迫,从而促进神经功能恢复,但对于手术时机的选择应个体化。药物治疗主要通过减轻继发性损伤和促进神经再生来发挥神经保护作用。细胞治疗作为急性脊髓损伤最有应用前景的治疗方式,仍需在移植细胞如何重建脊髓结构和功能上进一步探索。本文就当前治疗进展进行综述,为临床上有效治疗急性脊髓损伤提供参考。Acute spinal cord injury results in sensory and motor dysfunction below the level of injury, which seriously affects patients’ quality of life. In recent years, with the deepening studies on pathological mechanism of spinal cord injury, progress has been made in the treatment of acute spinal cord injury. Surgical treatment can rebuild spinal stability and relieve spinal cord compression,resulting in promoting the recovery of neural function, and the timing of surgery should be individualized to patients. Drug therapy plays aneuroprotective role mainly by alleviating secondary injury and promoting nerve regeneration. Cell therapy is the most promising future treatments for acute spinal cord injury;however, how transplanted cell reconstruct the spinal cord structure and function requires further exploration. This article reviews some of the current advances of the treatment in order to provide reference for clinical treatment of acute spinal cord injury.

关 键 词：脊髓损伤 治疗学 急性期 治疗进展 

分 类 号：R651.2[医药卫生—外科学]