不同他汀类治疗老年冠心病伴高胆固醇血症的疗效比较  

Comparison of Therapeutic Effects of Different Statins on Elderly Patients with Coronary Heart Disease and Hypercholesterolemia

作　　者：钱鹏[1] 王心慧[1] 曹选超[1] 徐先静[1] 黄改荣[1] 段明勤[1] Qian Peng(Department of Geriatrics,Henan people’s Hospital,Zhengzhou Henan 450003)

机构地区：[1]河南省人民医院老年医学科,河南郑州450003

出　　处：《黑龙江医药》2021年第1期9-12,共4页Heilongjiang Medicine journal

基　　金：河南省医学科技攻关计划普通项目(编号:201602226)。

摘　　要：目的:比较不同他汀类治疗老年冠心病伴高胆固醇血症的疗效。方法:选择2016年11月—2019年11月在河南省人民医院治疗的360例老年冠心病伴高胆固醇血症患者,随机分为A、B、C三组进行不同他汀类治疗,向A组(n=120)提供普伐他汀,B组(n=120)提供瑞舒伐他汀,C组(n=120)提供阿托伐他汀,比较三组不同他汀类治疗后的效果。结果:在血脂水平比较上,三组在治疗后的各项血脂指标上均表现好于治疗前;B组总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)上的表现较A、C两组更好,差异具有统计学意义,P<0.05。结论:不同他汀类药物在治疗老年冠心病上都能够取得较好疗效,安全性有保障,但相对来说,瑞舒伐他汀的疗效更佳,在临床应用更广。Objective:To compare the therapeutic effect of different statins on senile coronary heart disease with hypercholesterolemia.Method:360 elderly patients with coronary heart disease and hypercholesterolemia who were treated in Henan people’s Hospital from November 2016 to November 2019 were randomly divided into three groups:A,B and C for different statins.Pravastatin was provided to group A(n=120),rosuvastatin was provided to group B(n=120),and atorvastatin was provided to group C(n=120).The effects of different statins in three groups were compared.Result:In the comparison of blood lipid level,all the blood lipid indexes of three groups after treatment were better than before treatment;the total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)of group B were better than those of group A and C,the difference was statistically significant(P<0.05).Conclusion:Different statins can achieve better efficacy and safety in the treatment of elderly coronary heart disease,but relatively speaking,rosuvastatin has better efficacy and wider clinical application.

关 键 词：老年冠心病 伴高胆固醇血症 他汀类 

分 类 号：R541.4[医药卫生—心血管疾病]