NKCC1 and NKCC2:The pathogenetic role of cation-chloride cotransporters in hypertension  

作　　者：Sergei N.Orlov Svetlana V.Koltsova Leonid V.Kapilevich Svetlana V.Gusakova Nickolai O.Dulin 

机构地区：[1]Faculty of Biology,M.V.Lomonosov Moscow State University,Russia [2]Tomsk State University,Russia [3]Siberian State Medical University,Russia [4]University of Chicago Department of Medicine,USA

出　　处：《Genes & Diseases》2015年第2期186-196,共11页基因与疾病（英文）

基　　金：This work was supported by grants from the Canadian Institutes for Health Research(MOP-81392)(S.N.O.);Russian Foundation for Fundamental Research##14-04-31705(S.V.K.),15-04-00101(S.N.O.);the Russian Scientific Foundation#14-15-00006(S.N.O.);the USA National Institutes of Health Award R01-GM85058(N.O.D.).

摘　　要：This review summarizes the data on the functional significance of ubiquitous(NKCC1)and renal-specific(NKCC2)isoforms of electroneutral sodium,potassium and chloride cotransporters.These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid,respectively.Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume.However,the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.

关 键 词：HYPERTENSION Intracellular chloride Myogenic tone Neuronal cell NKCC cotransport Smooth muscle 

分 类 号：R54[医药卫生—心血管疾病]