早产儿脑损伤治疗热点的研究进展  

Research progress in the treatment of brain injury in premature infants

作　　者：刘春丽[1] 刘春枝[1] 王秀[1] 周雅勤 胡亚楠[1] LIU Chun-li;LIU Chun-zhi;WANG Xiu;ZHOU Ya-qin;HU Ya-nan(Neonatology Department,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院新生儿科,呼和浩特010050

出　　处：《实用药物与临床》2021年第2期176-180,共5页Practical Pharmacy and Clinical Remedies

基　　金：内蒙古自治区自然科学基金项目[2017MS(LH)0831];内蒙古医科大学青年创新基金(YKD2016QNCX023)。

摘　　要：随着围生医学的发展,早产儿尤其是极低及超低出生体重儿的存活率显著提高。但研究表明,早产儿脑损伤所致的神经系统方面的不良预后发生率并未随着其存活率升高而降低,成为其生存及远期预后的重要影响因素。越来越多的研究者期待应用药物或其他可行性的治疗手段及方案,以更好地干预早产儿脑损伤,提高早产儿生存率并改善远期预后。本文将目前研究热点进行归纳整理,从药物治疗及非药物治疗两个方面进行综述,但由于国内仍缺少大样本多中心的随机对照研究实验,且多数研究尚处于动物实验和临床研究阶段,产前预防性应用硫酸镁及促红细胞生成素治疗成为目前得到最多支持的研究热点。故建议早产儿脑损伤的治疗仍以预防性为主,尽量避免早产发生,预防并积极治疗感染,减少缺氧缺血发生,合理应用支持治疗等。Objective With the development of perinatal medicine,the survival rate of premature infants,especially those with very low and extremely low birth weight,is significantly increased.However,studies have shown that the incidence of neurological adverse prognosis of premature infants caused by brain injury does not decrease with the increase of their survival rate,which has become an important factor affecting their survival and long-term prognosis.More and more researchers expect to apply drugs or other feasible treatment methods and programs to better intervene the brain injury of premature infants,improve the survival rate of premature infants and improve the long-term prognosis.This article will present research hotspots to conclude,from two aspects of drug therapy and non-drug therapy reviewed,but still lack of large samples due to domestic multicenter randomized controlled experiment,and most of the research was still in the stage of animal experiment and clinical research,the prophylactic use of magnesium sulfate prenatal and erythropoietin treatment become a hot research topic which get the most support.Therefore,it is suggested that the treatment of brain injury in premature infants should still focus on prevention,try to avoid the occurrence of preterm birth,prevent and actively treat infection,reduce the occurrence of hypoxia and ischemia,and rationally apply supportive treatment.

关 键 词：早产儿脑损伤 硫酸镁 促红细胞生成素 细胞移植 惰性气体 

分 类 号：R722.6[医药卫生—儿科]