关节腔渗透压调控骨关节炎的研究进展  

Research progress on the regulation of osmotic pressure in osteoarthritis

作　　者：谢俊雄 邓志钦 张宁峰 李文翠[3] 段莉[2] 王大平 Xie Junxiong;DengZhiqin;Zhang Ningfeng;Li Wencui;Duan Li;WangDaping(University of South China,Hengyang Hunan,421001;Shenzhen Key Laboratory of Tissue Engineering,Shenzhen National Key Department of Orthopedics,Laboratory of Digital Orthopedic Engineering,Shenzhen Guangdong,518035;Peripheral Neurohandfoot Surgery Shenzhen Second People's Hospital,Shenzhen Guangdong,518035,China.)

机构地区：[1]南华大学,湖南衡阳421001 [2]深圳市组织工程重点实验室,深圳市数字骨科技术工程实验室,深圳市第二人民医院国家重点骨科,广东深圳518035 [3]深圳市第二人民医院周围神经手足外科,广东深圳518035

出　　处：《生物骨科材料与临床研究》2021年第1期55-58,共4页Orthopaedic Biomechanics Materials and Clinical Study

基　　金：国家自然科学基金项目(81800785);中国博士后基金项目(2018M633243);广东省自然科学基金-博士启动项目(2018A0303100027);深圳市卫计委博士启动项目(SZBC2018015)。

摘　　要：骨关节炎是一种慢性、进行性、不可逆性的关节退行性疾病,是一种中老年人的常见疾病,被认为是全球致残率较高的疾病之一。近年来,随着经济发展和人口老龄化,骨关节炎的患者数量在不断增加,这也让骨关节炎在临床上得到了极大的重视。而临床上治疗骨关节炎的一个关键性问题是关节软骨的丢失和难以自我修复。渗透压可以通过调节细胞体积和调控离子通道影响软骨细胞的生理代谢,从而影响关节软骨的损伤和修复。这一过程可能在骨关节炎发生发展中起到了重要作用。本文就离子通道、渗透压和骨关节炎三者间的相关性作一综述。Osteoarthritis(OA),a chronic progressive and irreversible disease with degeneration of articular cartilage,targeting mostly on the middle-aged and the elderly,is regarded as one of the most common disease causing disability globally.In recent years,with the economic development and population aging,the patients with OA augment,which attracts greater attention on the clinical treatment of this disease.Osmotic pressure has shown remarkable promise in the physiological metabolism of chondrocyte by regulating ion channel and cellular volume,then resulting in the influence on damage and repairment of articular cartilage.A better understanding of this process how to play an important role in OA is needed to improve treatment.This paper will try to unveil the correlation among ion channel,osmotic pressure and OA.

关 键 词：骨关节炎 软骨细胞 渗透压 细胞体积 离子通道 

分 类 号：R684.3[医药卫生—骨科学]