右美托咪定和丙泊酚对抑制患儿七氟烷吸入麻醉苏醒期躁动的临床治疗效果  

Clinical Effect of Dexmedetomidine and Propofol on Inhibiting Restlessness during Recovery from Sevoflurane Inhalation Anesthesia in Children

作　　者：郭纪东[1] 刘华[1] 祝兵[1] 张卫东[1] 梅荣 GUO Ji-dong;LIU Hua;ZHU Bing;ZHANG Wei-dong;MEI Rong(Department of Anesthesiology,Dongtai People's Hospital,Dongtai,Jiangsu Province,224200 China)

机构地区：[1]江苏省东台市人民医院麻醉科,江苏东台224200

出　　处：《系统医学》2020年第24期97-99,共3页Systems Medicine

摘　　要：目的分析对应用七氟烷吸入麻醉实施手术治疗的患儿结合应用右美托咪定、丙泊酚对苏醒期躁动的预防作用。方法以2017年1月-2020年3月81例手术患儿为对象,按照入院顺序分为两组,丙泊酚组40例应用丙泊酚预防苏醒期躁动,右美托咪定组41例应用右美托咪定预防苏醒期躁动,比较结果。结果右美托咪定组术后1 h到术后6 h的切口疼痛程度WHO评分均与丙泊酚组差异无统计学意义(P>0.05)。右美托咪定组术后苏醒时间为(18.75±4.91)min,丙泊酚组术后苏醒时间为(19.04±5.24)min;右美托咪定组苏醒期躁动发生率为12.20%,丙泊酚组苏醒期躁动发生率15.00%(t=0.257、χ^2=0.136,P>0.05)。右美托咪定组术后不良反应发生率为12.20%,与丙泊酚组术后不良反应发生率15.00%,差异无统计学意义(χ^2=0.136,P>0.05)。结论对接受七氟烷吸入麻醉的手术患儿,应用右美托咪定、丙泊酚均有预防苏醒期躁动、控制疼痛的作用,临床可根据实际情况选择具体药物。Objective To analyze the preventive effect of combined application of dexmedetomidine and propofol on restlessness during recovery period in children undergoing surgical treatment with sevoflurane inhalation anesthesia.Methods From January 2017 to March 2020,81 children undergoing surgery were divided into 2 groups according to the order of admission,40 cases of propofol group used propofol to prevent agitation during recovery,and 41 cases of dexmedetomidine group using dexmedetomidine to prevent restlessness during recovery period,compare the results.Results The WHO score of incision pain in the dexmedetomidine group from 1 hour to 6 hours after the operation was not statistically significantly different from that of the propofol group(P>0.05).The postoperative recovery time of the dexmedetomidine group was(18.75±4.91)min,and the postoperative recovery time of the propofol group was(19.04±5.24)min;the incidence of agitation in the dexmedetomidine group was 12.20%,Incidence of restlessness during the recovery period in the profol group was 15.00%(t=0.257,χ^2=0.136,P>0.05).The incidence of adverse reactions in the dexmedetomidine group was 12.20%,and there was no statistically significant difference in the incidence of adverse reactions in the propofol group of 15.00%(χ^2=0.136,P>0.05).Conclusion For children undergoing sevoflurane inhalation anesthesia,the application of dexmedetomidine and propofol can prevent restlessness and control pain during the recovery period.Specific drugs can be selected according to the actual situation.

关 键 词：右美托咪定 丙泊酚 七氟烷 吸入麻醉 苏醒期 躁动 

分 类 号：R614[医药卫生—麻醉学]