替诺福韦酯治疗慢性乙型肝炎的临床效果研究  

Study on the Clinical Effect of Tenofovir Dipivoxil in the Treatment of Chronic Hepatitis B

作　　者：魏玮[1] WEI Wei(Department of Infectious Diseases,People's Hospital of Pizhou City,Pizhou,Jiangsu Province,221300 China)

机构地区：[1]江苏省邳州市人民医院传染科,江苏邳州221300

出　　处：《中外医疗》2020年第35期66-68,共3页China & Foreign Medical Treatment

摘　　要：目的阐述罹患慢性乙型肝炎病症患者经替诺福韦酯治疗的疗效。方法此次研究时间为2017年4月—2019年10月,研究对象为方便选择期间收治罹患慢性乙型肝炎的患者78例,对其进行随机分组,对照组采用恩替卡韦治疗,观察组采用替诺福韦酯治疗,对比两组临床疗效,检测并记录各组患者用药前后肝功能各项指标变化,分析差异情况,同时比较各组患者治疗半年、1年后ALT复常率及HBV DNA转阴率、HBeAg转阴率。结果观察组此次治疗总效果相较对照组更优,差异有统计学意义(P<0.05)。两组患者用药前肝功能相应检测指标基本相近,差异无统计学意义(P>0.05),用药治疗一段时间后,均有一定改善,观察组患者ALT指标(32.89±10.13)U/L、AST指标(37.94±8.37)U/L、TBIL指标(17.48±2.01)mol/L均较对照组更低,Alb指标(36.01±2.11)g/L明显高于对照组,差异有统计学意义(t=19.440、15.650、13.030、11.930,P<0.05)。两组患者治疗半年后复常率、转阴率等无明显差异,而治疗1年后观察组患者ALT复常率、HBV DNA转阴率、HBeAg转阴率均明显高于对照组,差异有统计学意义(P<0.05)。结论慢性乙型肝炎患者经替诺福韦酯治疗效果更佳,可改善患者肝功能,ALT复常率高,安全性好。Objective To describe the curative effect of tenofovir dipivoxil in patients with chronic hepatitis B.Methods From April 2017 to October 2019.78 patients with chronic hepatitis B were conveniently admitted during the selection period of the study subjects,and they were randomly divided into groups,the control group Entecavir was used for treatment,and the observation group was treated with tenofovir dipivoxil.The clinical effects of the two groups were compared.The changes in liver function indexes of patients in each group were detected and recorded before and after medication,and differences were analyzed.At the same time,patients in each group were compared for half a year and one year.After ALT return to normal rate,HBV DNA negative rate,HBeAg negative rate.Results The total effect of this treatment in the observation group was better than that in the control group,the difference was statistically significant(P<0.05).The corresponding test indexes of liver function of the two groups of patients before medication were basically similar,the difference was not statistically significant(P>0.05),and after a period of medication,they all improved to a certain extent.The ALT index of the observation group was(32.89±10.13)U/L,AST index(37.94±8.37)U/L and TBIL indexes(17.48±2.01)mol/L were lower than those of the control group,and the Alb index(36.01±2.11)g/L was significantly higher than the control group,the difference was statistically significant(t=19.440,15.650,13.030,11.930,P<0.05).There was no significant difference in the normalization rate and negative conversion rate between the two groups of patients after half a year of treatment.After one year of treatment,the ALT normalization rate,HBV DNA conversion rate,and HBeAg conversion rate of the observation group were significantly higher than those of the control group,the difference was statistically significant(P<0.05).Conclusion Tenofovir dipivoxil has a better treatment effect in patients with chronic hepatitis B,which can improve the liver function of

关 键 词：替诺福韦酯 慢性乙型肝炎 临床效果 ALT复常率 

分 类 号：R512[医药卫生—内科学]