血清铁调素-25水平与2型糖尿病肾病的相关性分析  

Correlation Analysis between Serum Hepcidin-25 Level and Type 2 Diabetic Nephropathy

作　　者：劳万生 LAO Wan-sheng(Department of Internal Medicine,Section Two,the Fifth People's Hospital of Foshan City,Foshan,Guangdong Province,528211 China)

机构地区：[1]佛山市第五人民医院内二科,广东佛山528211

出　　处：《糖尿病新世界》2020年第24期69-71,共3页Diabetes New World Magazine

摘　　要：目的探讨血清铁调素-25水平与2型糖尿病肾病的相关性。方法选择2019年1—12月在该院肾内科就诊的2型糖尿病肾病患者97例,分为维持性血液透析组、持续性不卧床腹膜透析组、未透析慢性肾脏病组,另选30名健康人为健康体检组。检测并比较4组受试者的血红蛋白、尿素氮、血肌酐、铁调素-25水平变化情况。结果①在血红蛋白方面,与健康体检组比较,其余3组均明显下降,差异有统计学意义(P<0.05);未透析慢性肾脏病组、持续性不卧床腹膜透析组、维持性血液透析组血红蛋白水平随病情进展,逐渐下降,差异有统计学意义(P<0.05);与维持性血液透析组比较,持续性不卧床腹膜透析组血红蛋白水平无明显改变,差异无统计学意义(P>0.05)。②在尿素氮方面,与健康体检组比较,其余3组均明显上升,差异有统计学意义(P<0.05);未透析慢性肾脏病组、持续性不卧床腹膜透析组、维持性血液透析组尿素氮水平随病情进展,逐渐上升,差异有统计学意义(P<0.05);③在血肌酐方面,未透析慢性肾脏病组、持续性不卧床腹膜透析组、维持性血液透析组血肌酐水平随病情进展,逐渐上升,差异有统计学意义(P<0.05);④在铁调素-25水平方面,与健康体检组比较,其余3组均明显上升,差异有统计学意义(P<0.05);未透析慢性肾脏病组、持续性不卧床腹膜透析组、维持性血液透析组铁调素-25水平随病情进展,逐渐上升,差异有统计学意义(P<0.05)。结论2型糖尿病肾脏病变患者,随着肾功能下降,血红蛋白下降,铁调素-25水平逐渐上升,与病情进展有相关性。Objective To investigate the relationship between serum hepcidin-25 level and type 2 diabetic nephropathy.Methods Selected 97 patients with type 2 diabetic nephropathy who were treated in the nephrology department of the hospital from January to December 2019,and they were divided into maintenance hemodialysis group;continuous ambulatory peritoneal dialysis group;non-dialysis chronic kidney disease group.Another 30 healthy people were selected into the health examination group.The changes in hemoglobin,urea nitrogen,blood creatinine,and hepcidin-25 levels of the four groups of subjects were detected and compared.Results 1.n terms of hemoglobin,compared with the healthy physical examination group,the other three groups all decreased significantly,and the difference was statistically significant(P<0.05);the non-dialysis chronic kidney disease group,the continuous ambulatory peritoneal dialysis group,and the maintenance blood hemoglobin level of the dialysis group gradually decreased with the progress of the disease,and the difference was statistically significant(P<0.05);compared with the maintenance hemodialysis group,the hemoglobin level of the continuous ambulatory peritoneal dialysis group did not change significantly,the difference was not statistically significant(P>0.05).2.In terms of urea nitrogen,compared with the healthy physical examination group,the other three groups all increased significantly,and the difference was statistically significant(P<0.05);the non-dialysis chronic kidney disease group,the continuous ambulatory peritoneal dialysis group,and the maintenance blood level of urea nitrogen in the dialysis group gradually increased with the progress of the disease,and the difference was statistically significant(P<0.05);3.In terms of serum creatinine,the chronic kidney disease group without dialysis,the continuous ambulatory peritoneal dialysis group,and the maintenance hemodialysis group;the blood creatinine level in the group increased gradually with the progress of the disease,and the difference

关 键 词：血清铁调素-25 2型糖尿病肾病 持续性不卧床腹膜透析 维持性血液透析 

分 类 号：R587[医药卫生—内分泌]