基于网络药理学研究鸡眼草治疗2型糖尿病的药效物质基础  

Study on the effective substance basis of Jiyancao in the treatment of type 2 diabetes based on network pharmacology

作　　者：王新雨[1,2] 李子行 王丽[1] 胡明月[1] WANG Xin-Yu;LI Zi-Hang;WANG Li(Lingnan Institute of Technology,Guangzhou 510663,China;不详)

机构地区：[1]广东岭南职业技术学院,广州510663 [2]广东罗浮山国药股份有限公司,广东惠州516133

出　　处：《中国处方药》2021年第2期1-3,共3页Journal of China Prescription Drug

基　　金：2017年广东高校青年创新人才类项目(2017GkQNCX123)。

摘　　要：目的研究鸡眼草治疗2型糖尿病的药效物质基础,为鸡眼草的应用提供新的方向。方法以口服生物利用度(OB)≥20%、类药性(DL)≥0.18%为指标,借助中药系统药理学数据库及分析平台(TCMSP)筛选鸡眼草的活性成分;通过检索蛋白质数据库(Uniprot)和GeneCards数据库获取鸡眼草治疗2型糖尿病的作用靶点;利用生物学信息注释数据库(DAVID)对靶点京都基因与基因组百科全书(KEGG)通路富集分析。结果从鸡眼草中共筛选出活性成分9个,与2型糖尿病相关的作用靶点37个。鸡眼草治疗2型糖尿病的主要成分为槲皮素、木犀草素、山奈酚等。结论本研究采用网络药理学分析了鸡眼草治疗2型糖尿病的物质基础,可为进一步研究鸡眼草治疗2型糖尿病的药效物质基础及作用靶点提供参考。Objective To study the material basis of Jiyancao in the treatment of type 2 diabetes,and to provide a new direction for the application of Jiyancao.Methods Oral bioavailability(OB)≥20%,drug like(DL)≥0.18%was used as the index,the active components of Jiyancao were screened by using TCM systematic pharmacological analysis platform(TCMSP),the target of Jiyancao in the treatment of type 2 diabetes was obtained by searching UniProt and genecards database,target genes were analyzed by KEGG pathway enrichment analysis were performed by using DAVID database.Results A total of 9 active components of Jiyancao and 37 targets related to type 2 diabetes were screened.Quercetin,luteolin and kaempferol are the main components of Jiyancao in the treatment of type 2 diabetes.Conclusion This study analyzed the material basis of Jiyancao in the treatment of type 2 diabetes by network pharmacology,which can provide reference for further study on the material basis and target of Jiyancao in the treatment of type 2 diabetes.

关 键 词：鸡眼草 2型糖尿病 网络药理学 物质基础 

分 类 号：R285[医药卫生—中药学]