高效液相色谱手性拆分杀菌剂啶菌唑异构体  

Chiral Resolution of Pyrisoxazole by HPLC

作　　者：李子亮 包宁[2] 孟宪梅 朱建荣 于飞 于东锦 程春生 LI Zi-liang;BAO Ning;MENG Xian-mei;ZHU Jian-rong;YU Fei;YU Dong-jin;CHENG Chun-sheng(School of Material Science and Engineering,Shenyang University of Technology,Shenyang 110870,China;Shenyang Sciencreat Chemicals Co.,Ltd.,Shenyang 110144,China;Chemical Industry Safety Technology&Engineering Center,Shenyang Research Institute of Chemical Industry,Shenyang 110021,China)

机构地区：[1]沈阳工业大学材料科学与工程学院,沈阳110870 [2]沈阳科创化学品有限公司,沈阳110144 [3]沈阳化工研究院有限公司化工安全技术与工程中心,沈阳110021

出　　处：《农药》2021年第2期111-114,共4页Agrochemicals

基　　金：2019年度辽宁省科技重大专项项目(2019JH1/10300002)。

摘　　要：[目的]建立一种分离啶菌唑4种异构体的高效液相色谱分析方法。[方法]采用反相高效液相色谱法,使用资生堂Chiral CD-Ph色谱柱,以甲醇-乙酸水为流动相,在220 nm下进行分析。[结果]啶菌唑4种异构体的出峰时间分别为8.9、10.1、11.5、12.9 min,分离度R为5.45、2.00、2.00、1.62,符合要求,分离良好。[结论]该方法简单,准确,可将啶菌唑4种异构体完全分离。[Aims] This study aims to establish a HPLC method for the separation of four isomers of racemic pyrisoxazole. [Methods] The analysis of pyrisoxazole was carried out by RP-HPLC using Chiral CD-Ph column with the mixture solution of methanol and acetic acid water. The wave length of UV detector was 220 nm. [Results] The retention time of the four isomers was 8.9, 10.1, 11.5, 12.9 min, the resolution R is 5.45, 2.00, 2.00, 1.62, meeting the requirements. [Conclusions] The method is simple and accurate, and can completely separate four chiral isomers of racemic pyrisoxazole.

关 键 词：啶菌唑 高效液相色谱 手性拆分 

分 类 号：TQ450.7[化学工程—农药化工]