ANA细胞质荧光模式在ANCA相关血管炎中的临床意义  

Cytoplasmic ANA-fluorescence model in ANCA associated vasculitis

作　　者：张乃丹[1] 刘利洪[1] 邹雨沙 李白露 杨浩 唐灵 彭美君 张雪文 袁成良[1] ZHANG Naidan;LIU Lihong;ZOU Yusha;LI Bailu;YANG Hao;TANG Ling;PENG Meijun;ZHANG Xuewen;YUAN Chengliang(Department of Clinical Laboratory,Deyang People′s Hospital,Deyang,Sichuan 618000,China;Department of Laboratory Science,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610072,China;Department of Laboratory Science,North Sichuan Medical College,Nanchong,Sichuan 637100,China)

机构地区：[1]德阳市人民医院检验科,四川德阳618000 [2]成都中医药大学检验系,四川成都610072 [3]川北医学院检验系,四川南充637100

出　　处：《国际检验医学杂志》2021年第4期447-452,共6页International Journal of Laboratory Medicine

基　　金：德阳市科技局项目(2018S2S088);成都中医药大学医院专项课题(YYZX2019026);成都中医药大学校级教育教学改革研究项目(JGJD201933)。

摘　　要：目的分析抗核抗体(ANA)细胞质荧光模式在抗中性粒细胞细胞质抗体(ANCA)相关血管炎(AAV)中的特征,探讨ANA细胞质荧光模式在AAV中的意义。方法将德阳市人民医院232例进行了间接免疫荧光法(IIF)ANA和ANCA检测的AAV确诊患者纳入研究,并根据IIF-ANA的检测结果分为ANA细胞质荧光模式组与对照组。收集纳入研究患者的临床资料和临床实验室检测数据,将上述资料/数据在ANA细胞质荧光模式组与对照组间进行比较,分析ANA荧光模式与ANCA荧光模式的关系。结果两组间AAV患者胸部受累和心血管受累情况比较,差异有统计学意义(P<0.05)。线性回归分析显示,抗髓过氧化物酶抗体是ANA细胞质荧光模式组患者血肌酐水平的影响因素(P<0.001)。pANCA组和xANCA组ANA细胞质颗粒型检出率高于cANCA组(P<0.017)。结论ANA细胞质荧光模式与AAV的部分临床表现和实验室检查结果具有一定相关性。Objective To analyze the clinical characteristics and significance of cytoplasmic antinuclear antibody(ANA)-fluorescence model in patients with anti-neutrophil cytoplasmic antibody(ANCA)associated vasculitis(AAV).Methods A total of 232 patients in Deyang People′s Hospital diagnosed with AAV were enrolled in the study who both had undergone IIF-ANA and-ANCA test,and were devided into cytoplasmic ANA-fluorescence model group and control group according to the IIF-ANA test results.The clinical and laboratory data of those people were collected.Data were compared between the cytoplasmic ANA-fluorescence model group and the control group and the relationship between the cytoplasmic ANA-fluorescence model and different ANCA fluorescence models were analyzed.Results Chest involvement and cardiovascular involvement rates were significantly different between the cytoplasmic ANA-fluorescence model group and control group(P<0.05).Linear regression analysis showed that the anti-MPO antibody(anti-MPO)in the cytoplasmic ANA-fluorescence model group significantly effected the level of creatinine(P<0.001).The detection rate of cytoplasmic granular model in pANCA group and xANCA group was higher than that in cANCA group(P<0.017).Conclusion Cytoplasmic ANA-fluorescence model have certain correlation with the clinical manifestations and laboratory test results of AAV patients.

关 键 词：抗核抗体 抗中性粒细胞细胞质抗体 细胞质荧光模式 血管炎 

分 类 号：R446.61[医药卫生—诊断学]