变应性鼻炎患者血清OPN、NF-κB与sIgE水平的相关性  

Correlation between serum OPN,NF-κB and sIgE levels in patients with allergic rhinitis

作　　者：董春花[1] 马新春[1] 张英[1] DONG Chunhua;MA Xinchun;ZHANG Ying(Department of Otolaryngology,Affiliated Hospital of Qinghai University,Xining,Qinghai 810001,China)

机构地区：[1]青海大学附属医院耳鼻喉科,青海西宁810001

出　　处：《国际检验医学杂志》2021年第4期473-475,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨血清骨桥蛋白(OPN)、核转录因子-κB(NF-κB)水平与变应性鼻炎患者特异性免疫球蛋白E(sIgE)的相关性。方法选取2017年6月至2019年7月到该院就诊的85例变应性鼻炎患者作为变应性鼻炎组;将患者按严重程度分组:轻度31例、中-重度组54例;按变应性鼻炎类型分组:间歇性组44例、持续性组41例。比较各组间血清OPN、NF-κB、sIgE水平及鼻部症状总评分(TNSS)。采用Pearson相关分析变应性鼻炎患者OPN、NF-κB、sIgE水平与TNSS的相关性,多元线性回归相关分析变应性鼻炎患者sIgE水平的影响因素。结果变应性鼻炎组血清OPN、NF-κB、sIgE水平均高于对照组(P<0.05)。中-重度组血清OPN、NF-κB、sIgE水平及TNSS均高于轻度组(P<0.05)。间歇性组和持续性组间血清OPN、NF-κB、sIgE水平及TNSS比较,差异均无统计学意义(P>0.05)。Pearson相关性分析显示,变应性鼻炎患者OPN、NF-κB、sIgE水平与TNSS均呈正相关(r=0.543、0.581、0.642,P<0.05),OPN、NF-κB与sIgE均呈正相关(r=0.603、0.615,P<0.05)。多元线性回归分析显示,OPN、NF-κB是变应性鼻炎患者sIgE的独立影响因素。结论OPN、NF-κB与变应性鼻炎密切相关,可能参与其发病过程。Objective To investigate the correlation between serum osteopontin(OPN)and nuclear transcription factor(NF-κB)and specific immunoglobulin E(sIgE)levels in patients with allergic rhinitis.Methods A total of 85 patients with allergic rhinitis who visited the hospital from June 2017 to July 2019 were enrolled in the study.The patients were divided into mild group(n=31)and moderate-severe group(n=54)according to the severity,and intermittent group(n=44)and persistent group(n=41)according to the type of allergic rhinitis.Serum OPN,NF-κB,sIgE levels and total nasal symptoms scores(TNSS)among the groups were compared.Pearson correlation was used to analyze the correlation between OPN,NF-κB,sIgE levels and TNSS in patients with allergic rhinitis.Multiple linear regression was used to analyze the influencing factors of sIgE levels in patients with allergic rhinitis.Results The levels of serum OPN,NF-κB and sIgE in the allergic rhinitis group were significantly higher than those in the control group(P<0.05).The levels of serum OPN,NF-κB,sIgE and TNSS in the moderate-severe group were significantly higher than those in the mild group(P<0.05).There were no significant differences in serum OPN,NF-κB,sIgE levels and TNSS between the intermittent group and the continuous group(P>0.05).Pearson correlation analysis showed that OPN,NF-κB,sIgE were positively correlated with TNSS in patients with allergic rhinitis(r=0.543,0.581,0.642,P<0.05),OPN,NF-κB and sIgE were positively correlated(r=0.603,0.615,P<0.05).Multiple linear regression analysis showed that OPN and NF-κB are independent influencing factors of sIgE levels in patients with allergic rhinitis.Conclusion OPN and NF-κB are closely related to allergic rhinitis and may participate in its pathogenesis.

关 键 词：骨桥蛋白 核转录因子 变应性鼻炎 特异性免疫球蛋白E 

分 类 号：R446.62[医药卫生—诊断学]