Free bisphenol A(BPA),BPA-Glucuronide(BPA-G),and total BPA concentrations in maternal serum and urine during pregnancy and umbilical cord blood at delivery  

作　　者：Warren G.Foster Cariton Kubwabo Ivana Kosarac Sandra Gregorovich Garima Aryal Kaela Coleman 

机构地区：[1]Department of Obstetrics&Gynaecology,McMaster University,Hamilton,Ontario,L8S 4K1,Canada [2]Environmental Health Science and Research Bureau,Health Canada,Ottawa,Ontario,K1A 0K9,Canada [3]Tobacco Control Directorate,Health Canada,Ottawa,Ontario,K1A 0K9,Canada

出　　处：《Emerging Contaminants》2019年第1期279-287,共9页新兴污染物（英文）

基　　金：The time and commitment of study participants to this project are greatly appreciated.Funding for this project was provided from Health Canada under the Chemicals Management Plan.

摘　　要：While adult exposure to total bisphenol A(BPA)has been well documented,developmental exposure to BPA and fetal exposure to the bioactive form(free BPA)remains poorly defined.Therefore,pregnant women(n?199)between 28 and 35 weeks of pregnancy were invited to participate in this study.Maternal serum free of hemolysis(n?189)and urine(n?112)were collected at third trimester and delivery along with umbilical cord blood(UCB)at delivery.Free BPA,BPA mono-glucuronide(BPA-G)and total BPA concentrations were measured using gas chromatography coupled with tandem mass spectrometry.Circulating concentrations of free BPA were quantifiable above the method detection limit(MDL?0.026 ng/mL)in approximately 34%of serum samples in the third trimester and 21%of samples at delivery whereas BPA-G and total BPA were quantified in 43 and 70%of third trimester and delivery samples,respectively.The geometric mean of free BPA,BPA-G and total BPA concentrations in maternal serum during the third trimester and at delivery were 0.62 ng/L and<MDL,0.09 and 0.28 ng/mL,and 0.24 and 0.31 ng/mL,respectively.Geometric mean urinary concentrations of free BPA,BPA-G,and total BPA(MDL?0.027 ng/mL)in the third trimester and delivery samples were 0.07 and 0.06 ng/mL,0.36 and 0.09 ng/mL,and 0.36 and 0.09 ng/mL,respectively.In the UCB,the geometric means for free BPA,BPA-G,and total BPA concentrations were 0.05,0.08 and 0.10 ng/mL,respectively.Our results suggest that,in our study population,free BPA concentrations were low compared to other Canadian cohorts.

关 键 词：Bisphenol A Free BPA Conjugated BPA PREGNANCY Exposure Fetal development Cord blood 

分 类 号：R11[医药卫生—公共卫生与预防医学]