水溶性药物脂质体制备方法的研究进展  

Progress on Preparation Method of Water-Soluble Drug Liposomes

作　　者：王荷逸 黄思凡 王邦国 武鑫 陈建明 WANG He-yi;HUANG Si-fan;WANG Bang-guo;WU Xin;CHEN Jian-ming(School of Pharmacy,Inner Mongolia Medical University,Hohhot 010110,China;School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Shanghai Weier Laboratory,Shanghai 201712,China)

机构地区：[1]内蒙古医科大学药学院,呼和浩特010110 [2]福建中医药大学药学院,福州350122 [3]上海维洱实验室,上海201712

出　　处：《中国药学杂志》2020年第23期1935-1938,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81772749);上海市青年科技启明星计划资助(18QB1400400);上海市科技小巨人工程项目资助(1902HX76600);上海青浦区产学研合作发展资金项目资助(青产学研2019-5)。

摘　　要：根据目前水溶性药物易泄漏、包封率低的不足,查阅近几年国内外相关文献,对其制备方法进行综述。总结水溶性药物脂质体制备方法的研究进展,为水溶性药物脂质体制备提供参考。脂质体包载水溶性药物在实验室研究中已取得不错的成果,但大工业生产较困难,还需深入研究。To summarize the research progress of the preparation methods of water-soluble drug liposomes and provide reference for the preparation of water-soluble drug liposomes. According to the current shortcomings of easy leakage of water-soluble drugs and low encapsulation rate, the preparation methods of water-soluble drugs were reviewed by referring to relevant literatures in recent years. Liposome-encapsulated water-soluble drug has achieved good results in laboratory research, but it is difficult to produce in large industry, and further research is needed.

关 键 词：水溶性药物 脂质体 制备方法 

分 类 号：R944[医药卫生—药剂学]