痛泻要方对溃疡性结肠炎患者中医证候及肠道菌群的影响  

Effect of Tongxieyaofang on traditional Chinese medicine syndrome and intestinal flora in patients with ulcerative colitis

作　　者：俞媛 王卿华 陈媛洁 李晨 张美云 YU Yuan;WANG Qinghua;CHEN Yuanjie;LI Chen;ZHANG Meiyun(Jiangning Hospital of Traditional Chinese Medicine,Nanjing 211100,Jiangsu,China;Xuzhou Hospital of Traditional Chinese Medicine,Xuzhou 221003,Jiangsu,China)

机构地区：[1]南京市江宁中医院,江苏南京211100 [2]徐州市中医院,江苏徐州221003

出　　处：《湖南中医杂志》2020年第12期12-14,共3页Hunan Journal of Traditional Chinese Medicine

基　　金：江苏省南京市江宁区科技发展计划项目(2019SHSY0011)。

摘　　要：目的:观察痛泻要方对溃疡性结肠炎(UC)肝郁脾虚证的临床疗效及其对肠道菌群的影响。方法:将40例UC肝郁脾虚证患者随机分为治疗组和对照组,每组各20例。对照组予美沙拉嗪肠溶片治疗,治疗组在对照组基础上加用痛泻要方治疗。2组疗程均为12周,比较2组治疗前后中医证候积分及肠道菌群的变化。结果:治疗前,2组中医证候积分、主要肠道菌群数目比较,差异无统计学意义(P>0.05)。与治疗前比较,治疗后2组中医证候积分均降低,有益菌群(双歧杆菌、乳酸杆菌)数目均明显上升,而有害菌群(大肠埃希菌)数目明显下降,且治疗组的指标改善情况均优于对照组,差异有统计学意义(均P<0.05)。结论:痛泻要方可有效改善UC肝郁脾虚证患者的中医证候,纠正患者肠道菌群的紊乱,提高临床疗效。Objective: To investigate the clinical effect of Tongxieyaofang in the treatment of ulcerative colitis( UC) withstagnation of liver Qi and spleen deficiency and its effect on intestinal flora. Methods: A total of 40 UC patients with stagnation of liver Qi and spleen deficiency were randomly divided into treatment group and control group,with 20 patients in each group. The patients in the control group were given mesalazine enteric-coated tablets,and those in the treatment group were given Tongxieyaofang in addition to the treatment in the control group. The course of treatment was 12 weeks for both groups,and the two groups were compared in terms of the changes in traditional Chinese medicine( TCM)syndrome score and intestinal flora after treatment. Results: Before treatment,there were no significant differences in TCM syndrome score and number of major intestinal flora between the two groups( P>0. 05). After treatment,both groups had a significant reduction in TCM syndrome score,a significant increase in the number of beneficial flora( Bifidobacterium and Lactobacillus),and a significant reduction in the number of harmful flora( Escherichia coli),and the treatment group had significantly better improvements than the control group( all P < 0. 05). Conclusion: In UCpatients withstagnation of liver Qi and spleen deficiency,Tongxieyaofang can effectively improve TCM syndrome,alleviate intestinal flora disturbance,and improve treatment outcome.

关 键 词：溃疡性结肠炎 痛泻要方 中医证候 肠道菌群 

分 类 号：R259.746.2[医药卫生—中西医结合]