氯吡格雷联合依折麦布对冠心病心绞痛患者内皮功能及脂代谢的影响  

Effects of clopidogrel combined with ezetimibe on endothelial function and lipid metabolism in patients with coronary heart disease and angina pectoris

作　　者：柴娟娟 韩卫星[1] 张松文[2] CHAI Juan-juan;HAN Wei-xing;ZHANG Song-wen(Department of Cardiocardiology,The First Affiliated Hospital of Anhui Medical University,Hefei 230000,Anhui Province,China;Department of Cardiocardiology,The Second People’s Hospital of Hefei,Hefei 230000,Anhui Province,China)

机构地区：[1]安徽医科大学第一附属医院心电心功能科,安徽合肥230000 [2]合肥市第二人民医院心电心功能科,安徽合肥230000

出　　处：《中国临床药理学杂志》2021年第1期12-15,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察氯吡格雷联合依折麦布对冠心病心绞痛患者内皮功能及脂代谢的影响。方法将100例冠心病心绞痛患者,按随机数字表法分为对照组、试验组,各50例。对照组给予依折麦布,每次10 mg,每天1次,每晚服用;试验组在对照组的基础上给予氯吡格雷,每次75 mg,每天1次,每晚服用。2组均连续治疗12周。检测2组治疗前后内皮功能指标及血脂水平。结果治疗后,对照组与试验组血清一氧化氮(NO)水平分别为(62.26±5.43),(79.55±6.82)μmol·L^-1,血清内皮素-1(ET-1)水平分别为(82.54±9.34),(52.19±10.63)pg·L^-1,血清血管内皮细胞生长因子(VEGF)水平分别为(110.68±15.26),(192.65±19.37)ng·L^-1,血清总胆固醇(TC)水平分别为(4.34±0.23),(3.68±0.35)mmol·L^-1,血清三酰甘油(TG)水平分别为(2.09±0.21),(1.74±0.14)mmol·L^-1,血清高密度脂蛋白(HDL-C)水平分别为(1.19±0.32),(1.30±0.19)mmol·L^-1,血清低密度脂蛋白(LDL-C)水平分别为(3.39±0.27),(2.87±0.39)mmol·L^-1,差异均有统计学意义(均P<0.05)。试验组出现恶心2例,腹痛1例,过敏1例,药物不良反应发生率为8.00%;对照组出现恶心3例,呕吐2例,过敏2例,腹痛2例,药物不良反应发生率为18.00%。2组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合依折麦布治疗冠心病心绞痛有良好的疗效,可显著改善内皮功能指标,还能调节血脂紊乱,且安全性好。Objective To investigate the effects of clopidogrel combined with ezetimibe on endothelial function and lipid metabolism in patients with coronary heart disease and angina pectoris.Methods A total of 100 patients with coronary heart disease and angina pectoris were divided into control group and treatment group according to the random number table method,with 50 cases in each group.Control group was treated with ezetimibe 10 mg·time^-1,once a day,taken every night;treatment group was given clopidogrel 75 mg·time^-1,once a day,taken every night,on the basis of control group.Both groups were treated for 12 weeks.Endothelial function indicators and blood lipid levels were measured before and after treatment in two groups.Results After treatment,the levels of serum nitric oxide(NO)in control group and treatment group were(62.26±5.43),(79.55±6.82)μmol·L^-1,the levels of serum endothelin-1(ET-1)were(82.54±9.34),(52.19±10.63)pg·L^-1,the levels of serum vascular endothelial growth factor(VEGF)were(110.68±15.26),(192.65±19.37)ng·L^-1,the levels of serum total cholesterol(TC)were(4.34±0.23),(3.68±0.35)mmol·L^-1,the levels of serum triglyceride(TG)were(2.09±0.21),(1.74±0.14)mmol·L^-1,the levels of serum high-density lipoprotein cholesterol(HDL-C)were(1.19±0.32),(1.30±0.19)mmol·L^-1,the levels of serum low-density lipoprotein cholesterol(LDL-C)were(3.39±0.27),(2.87±0.39)mmol·L^-1,all with significant difference(all P<0.05).After treatment,there were 2 cases of nausea,1 case of abdominal pain and 1 case of allergy in treatment group,with the incidence of8.00%.After treatment,there were 3 cases of nausea,2 cases of vomiting,2 cases of allergyand 2 cases of abdominal painin control group,with the incidence of 18.00%,without significant difference(P>0.05).Conclusion Clopidogrel combined with ezetimibe in the treatment of coronary heart disease with angina pectoris can effectively improve the clinical treatment effect,improve the endothelial function index,regulate blood lipid disorders,with good safety.

关 键 词：氯吡格雷 依折麦布 冠心病心绞痛 内皮功能 血管内皮生长因子 血脂水平 

分 类 号：R972[医药卫生—药品]