益生菌作为添加治疗急性肠胃炎的疗效和降低急性肠胃炎腹泻时间的研究分析  

Efficacy of probiotics as an additive in the treatment of acute gastroenteritis and reduction of diarrhea time

作　　者：赵旭 曾朝涛[2] 张译文 陈珺仪 姜福林 伍俊妍[2] 黄民[1,2] 钟国平 ZHAO Xu;ZENG Chao-tao;ZHANG Yi-wen;CHEN Jun-yi;JIANG Fu-lin;WU Jun-yan;HUANG Min;ZHONG Guo-ping(Institute of Clinical Pharmacology,School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China;Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China)

机构地区：[1]中山大学药学院临床药理研究所,广东广州510080 [2]中山大学孙逸仙纪念医院,广东广州510080

出　　处：《中国临床药理学杂志》2021年第2期172-174,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的用Meta分析的方式评价益生菌对急性肠胃炎疗效。方法通过检索中外文献库,提取文献中的数据,对益生菌对急性肠胃炎有效率,显效率,腹泻时间进行Meta分析并汇总。结果共计纳入11篇文献,1221例患者,分析显示益生菌在进行急性肠胃炎治疗时的总体有效率的OR值为6.00,95%CI为(3.68,9.79),益生菌在进行急性肠胃炎治疗时的总体显效率的OR值为3.52,95%CI为(2.06,6.01),益生菌在进行急性肠胃炎治疗时降低腹泻时间的均属差(weighted mean difference,WMD)值为-0.79,95%CI为(-1.33,-0.24),且三项均有统计学意义。结论益生菌可以有效地治疗急性肠胃炎,建议临床上使用益生菌治疗急性肠胃炎。Objective To evaluate the efficacy of probiotics on acute gastroenteritis using Meta-analysis.Methods By searching literature libraries,extracting the data in the literature,Meta-analyze and summarize the probiotics’effectiveness,obvious efficiency and diarrhea time on acute gastroenteritis.Results A total of 11 articles were included in 1221 patients.The analysis showed that the overall effective rate of probiotics in the treatment of acute gastroenteritis was OR 6.00,95%CI=(3.68,9.79),obvious efficiency’s OR was 3.52,95%CI=(2.06,6.01),diarrhea time on acute gastroenteritis’s weighted mean difference(WMD)was-0.79,95%CI=(-1.33,-0.24).Conclusion Probiotics can effectively treat acute gastroenteritis.It is recommended to use probiotics to treat acute gastroenteritis clinically.

关 键 词：益生菌 急性肠胃炎 腹泻 有效率 显效率 

分 类 号：R97[医药卫生—药品]