苦味中药激活肠道苦味受体分泌胰高血糖素样肽-1的研究现状  

Current situation of bitter taste traditional Chinese medicine activating intestinal bitter taste receptors to secrete glucagon-like peptide-1

作　　者：李杰[1,2] 杨海梅[1,2] 宋秀道 江国荣 LI Jie;YANG Hai-mei;SONG Xiu-dao;JIANG Guo-rong(Clinical Pharmaceutical Laboratory of Traditional Chinese Medicine(TCM),Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,Jiangsu Province,China;School of Pharmacy,Nanjing University of TCM,Nanjing 210023,Jiangsu Province,China;Clinical Pharmaceutical Laboratory of TCM,Suzhou Academy of Wumen Chinese Medicine,Suzhou 215009,Jiangsu Province,China)

机构地区：[1]南京中医药大学附属苏州市中医医院中药临床药学实验室,江苏苏州215009 [2]南京中医药大学药学院,江苏南京210023 [3]苏州市吴门医派研究院中药临床药学实验室,江苏苏州215009

出　　处：《中国临床药理学杂志》2021年第2期179-182,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81973740)。

摘　　要：胰高血糖素样肽-1(GLP-1)可以刺激胰岛素释放以及抑制胰高血糖素释放,与2型糖尿病有关。苦味中药可以激活肠道上的苦味受体(TAS2Rs),通过磷脂酶C通路和磷酸二酯酶通路刺激肠道内分泌L细胞未分泌GLP-1,广泛用于2型糖尿病的防治。本文综述了苦味中药对肠道TAS2Rs介导的GLP-1分泌的调控作用,为苦味中药防治2型糖尿病提供新视角。Glucagon-like peptide-1(GLP-1)can inhibit the release of glucagon and stimulate the release of insulin,which is related to type 2 diabetes.Recently,studies have found that bitter taste traditional Chinese medicine activates intestinal tract bitter taste receptors(TAS2 R),and then promote GLP-1 secretion from intestinal endocrine L cells through activating phospholipase C pathway and phosphodiesterase pathway.Bitter taste traditional Chinese medicine is widely used in the prevention and treatment of type 2 diabetes mellitus.This article reviews bitter taste traditional Chinese medicine stimulates GLP-1 secretion mediated by intestinal TAS2 Rs and it provides new perspective for the prevention and treatment of type 2 diabetes mellitus with bitter taste traditional Chinese medicine.

关 键 词：苦味中药 苦味受体 L细胞 胰高血糖素样肽-1 2型糖尿病 

分 类 号：R28[医药卫生—中药学]