长期使用质子泵抑制剂致药源性显微镜结肠炎1例分析  

Case Analysis of Drug-induced Microscopic Colitis due to Long-term Use of Proton Pump Inhibitor

作　　者：孔彬[1] 林荣芳[2] 刘晓霞[1] KONG Bin;LIN Rongfang;LIU Xiaoxia(The Xinjiang Production and Construction Corps Hospital,Urumqi Xinjiang 830002,China;The First Affiliated Hospital of Fujian Medical University,Fuzhou Fujian 350001,China)

机构地区：[1]新疆生产建设兵团医院,新疆乌鲁木齐830002 [2]福建医科大学附属第一医院,福建福州350001

出　　处：《中国药物警戒》2021年第2期194-195,200,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的对1例长期服用质子泵抑制剂(PPI)治疗慢性腹泻,经病理组织学检查确诊为药源性显微镜结肠炎的罕见病例诊疗过程进行分析。方法查阅文献,并通过分析讨论药源性显微镜结肠炎的特点及PPI致药源性显微镜结肠炎的机制,对该病例中的药品不良反应进行判断和分析。结果不规律长期使用PPI很可能导致药源性显微镜结肠炎。结论临床药师利用药学专业知识及时发现临床诊疗中由于药品引起的不良反应,能为临床诊疗提供帮助,并为PPI在临床合理使用提供参考。Objective To analyze the process of diagnosing and treating a rare case of microscopic colitis detected during histopathological examination of a patient with chronic diarrhea,who had long been taking a proton pump inhibitor(PPI).Methods Related literature was reviewed while the characteristics of druginduced microscopic colitis and the mechanism of PPI-induced microscopic colitis were analyzed to determine the adverse drug reactions in this case.Results Irregular and long-term use of a PPI was likely to lead to druginduced microscopic colitis.Conclusion Clinical pharmacists ought to use their knowledge of pharmacy to quickly discover the adverse reactions caused by drugs in clinical diagnosis and treatment,which can provide reference for the rational use of PPIs in clinical practice.

关 键 词：显微镜结肠炎 质子泵抑制剂 药品不良反应 

分 类 号：R969.3[医药卫生—药理学]