Changed ACC-DMN functional connectivity after acupuncture with deqi for functional dyspepsia treatment  

针刺得气对功能性消化不良患者前扣带回-默认网络功能连接度的影响

作　　者：Rui-rui SUN Pei-hong MA Zhao-xuan HE Tao YIN Yu-zhu QU Shuai YIN Xiao-yan LIU Jin LU Ting-ting ZHANG Liu-yang HUANG Xue-ling SUO Du LEI Qi-yong GONG Fan-rong LIANG Fang ZENG 孙睿睿;马培宏;何昭璇;尹涛;瞿玉竹;印帅;刘小艳;卢晋;张婷婷;黄柳杨;索学玲;雷都;龚启勇;梁繁荣;曾芳(成都中医药大学针灸推拿学院/第三附属医院,中国四川成都611137;成都中医药大学针刺脑科学研究中心,中国四川成都611137;河南中医药大学第一附属医院,中国河南郑州450000;四川大学华西医院放射科/华西磁共振研究中心,中国河南郑州450000)

机构地区：[1]Acupuncture and Tuina School/The 3rd Teaching Hospital,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan Province,China [2]Acupuncture and Brain Research Center,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan Proovice,China [3]First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan Province,China [4]Huaxi MR Research Center(HMRRC),Departments of Radiology,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Acupuncture-Moxibustion》2021年第1期6-15,共10页世界针灸杂志（英文版）

基　　金：grants from the National Natural Science Foundation of Outstanding Youth Fund in China:81622052;National Natural Science Foundation of China:81473602;the major program of the National Natural Science Foundation of China:81590950;the Ten Thousand Talent Program:W02020595;Youth Science and Technology Innovative Team of Sichuan Province:2019JDTD0011。

摘　　要：Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD.Methods:Thirty-two FD patients and 35 healthy subjects(HS)were firstly scanned by the resting-state blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI)to compare differences of ACC-based functional connectivity(FC).Then 32 FD patients were randomized to receive 20 sessions’acupuncture treatment with(n=16)and without deqi(n=16),as well as underwent functional magnetic resonance imaging(fMRI)scans after treatment.After group re-division according to deqi response,changes of ACC subregions-based resting-state FC(rsFC)were compared between the actual with and without deqi group.Two seeds with bilateral of each were selected as regions of interest(ROIs)of the ACC,including two from the dorsal ACC:S2(BA24)(x=±5,y=2,z=46,r=3.5 mm)and two from the pregenual ACC:17(BA24)(x=±5,y=38,z=6,r=3.5 mm).The clinical changes of the Nepean Dyspepsia Index(NDI)that measuring symptoms and quality of life(QOL)were also used to further assess the correlation with ACC subregions rsFC in FD patients.Results:Compared to HS,FD patients showed significantly increased ACC subregions rsFC with left fusiform gyrus,temporal cortex,hippocampus(HIPP)/amygdala,temporal pole,and right INS,superior occipital gyrus,and bilateral precuneus,superior parietal lobule(SPL),and decreased rsFC with left postcentral/precentral gyrus(PoG/PrG),supplementary motor area(SMA)and right cerebellum.32 FD patients which were then re-divided into the actual deqi group(n=16)and actual without deqi group(n=16).The decrease of the NDI symptom score(pre-pos)in the actual deqi group was significantly greater than that in the actual without deqi group(P<0.05).Among the two groups,the actual deqi group showed increased ACC subregions rsFC with right SMA and bilateral PrG/PoG,and decreased rsFC with right precuneus,middle occipi

关 键 词：DEQI Functional dyspepsia ACC subregions RESTING-STATE Functional connectivity 

分 类 号：R246.1[医药卫生—针灸推拿学]