新型吲唑衍生物1-乙酸-吲唑-3-羧酸的合成  

Synthesis of A Novel Indazole Derivative 1-(carboxymethyl)-Indazole-3-carboxylic Acid

作　　者：张金龙 陶紫薇 李直坤 刘文俊 戎强 罗世鹏 ZHANG Jin-long;TAO Zi-wei;LI Zhi-kun;LIU Wen-jun;RONG Qiang;LUO Shi-peng(School of Chemical and Environmental Engineering,Jiangsu University of Technology,Jiangsu Changzhou 213001,China)

机构地区：[1]江苏理工学院化学与环境工程学院,江苏常州213001

出　　处：《广州化工》2021年第4期31-32,共2页GuangZhou Chemical Industry

基　　金：江苏省研究生实践创新计划(20820111972);江苏省产学研前瞻计划(BY2018200);江苏理工学院科研启动基金(KYY15011)。

摘　　要：吲唑羧酸衍生物具有潜在的生物活性,同时具有多配位中心的特点,容易与金属离子形成单核或多核金属有机配合物。本文以1-氢吲唑-3-羧酸为起始原料,经酯化,取代以及水解反应,通过3步合成了一种全新的吲唑双羧酸配体。中间体及最终产物经核磁共振氢谱、碳谱以及质谱确定。本方法合成步骤简洁,反应条件温和易操作,且各步骤均可重结晶纯化,无需柱层析等复杂步骤,能够大量合成。Indoxazole carboxylic acid derivatives have potential biological activities along with the characteristics of multiple coordination centers,which result in easily forming mononuclear or poly-nuclear organometallic complexes with metal ions.A novel ligand,1-(carboxymethyl)-indoxazole-3-carboxylic acid,was synthesized from 1-hydroindazole-3-carboxylic acid,by esterification,substitution and hydrolysis.The intermediates and final products were identified by ^(1)H NMR,^(13)C NMR and MS.This method is simple,mild and easy to operate.All the intermediates and products could be purified by recrystallization instead of column chromatography,and can be synthesized in large quantities.

关 键 词：吲唑-3-羧酸 氯乙酸乙酯 合成 配合物 

分 类 号：O621.3[理学—有机化学]