可变剪接的表观遗传学调控机制及其在脂肪代谢中的作用研究进展  

Advances in the Epigenetic Regulation Mechanism of Alternative Splicing and Its Role in Lipid Metabolism

作　　者：骞鑫 马海明[1] 何俊[1] 徐康[2] 张跃博 QIAN Xin;MA Haiming;HE Jun;XU Kang;ZHANG Yuebo(College of Animal Science and Technology,Hunan Agricultural University,Hunan Changsha 410128,China;Institute of Subtropical Agriculture,Chinese Academy of Sciences,Hunan Changsha 410125,China)

机构地区：[1]湖南农业大学动物科学技术学院,湖南长沙410128 [2]中国科学院亚热带农业生态研究所,湖南长沙410125

出　　处：《中国畜牧杂志》2021年第2期46-53,共8页Chinese Journal of Animal Science

基　　金：宁乡花猪基础研究(5026401-0315069);湖南省教育厅科学研究项目(19C0902);湖南省自然科学联合基金项目(2018JJ4003)。

摘　　要：可变剪接是指从1个mRNA前体中通过不同的剪接方式产生不同的mRNA剪接异构体,并使得最终的蛋白产物表现出不同或者相互拮抗的功能和结构特性的过程。基因通过可变剪接在组织发育和疾病中起着至关重要的作用,是高等真核生物蛋白质多样性的主要来源之一。剪接过程受多种因素调控,其中表观遗传学现象是可变剪接过程中重要的影响因素,多项研究表明多种表观遗传学现象对于可变剪接存在调控作用。可变剪接对于脂肪细胞的分化以及脂质的代谢也起到不可或缺的作用。本文综述了表观遗传学修饰对可变剪接的调控及其在脂肪代谢调控中的研究进展,以期为可变剪接的进一步研究提供参考依据。Alternative splicing refers to the process of producing different mRNA splicing isomers from one mRNA precursor by different splicing types.Consequently,the final proteins translated from the different mRNA splicing isomers show different or antagonistic functional and structural characteristics.It is an essential mechanism to increase protein diversity in higher eukaryotes and plays an important role in tissue development and diseases.The splicing process is regulated by many factors,among which epigenetics is an important factor.Many studies have revealed that a variety of epigenetic modifications plays an important role in regulating alternative splicing.Alternative splicing also plays an indispensable role in adipocyte differentiation and lipid metabolism.Here,we briefly review the regulation of epigenetic modification on alternative splicing and its research progress in regulation of lipid metabolism.This article could provide reference for the further study of alternative splicing.

关 键 词：可变剪接 表观遗传学 调控机制 脂肪代谢 

分 类 号：S813[农业科学—畜牧学]