慢性阻塞性肺疾病患者血清神经生长素受体的表达水平及其与慢性阻塞性肺疾病评估测试评分、BODE指数的相关性  

Expression level of serum nerve growth factor receptor in patients with chronic obstructive pulmonary disease and its correlation with chronic obstructive pulmonary disease assessment test score and BODE index

作　　者：李宁宁 甘文云 刘辉 李春苗 李海明 Li Ningning;Gan Wenyun;Liu Hui;Li Chunmiao;Li Haiming(Department of Respiratory and Critical Medicine,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]河南省驻马店市中心医院呼吸与危重症医学科,463000

出　　处：《临床内科杂志》2021年第2期109-112,共4页Journal of Clinical Internal Medicine

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者血清神经生长素受体(NGFR)的表达水平及其与慢性阻塞性肺疾病评估测试(CAT)评分、BODE指数的相关性。方法纳入COPD患者96例,包括54例急性加重期COPD(AECOPD)患者(AECOPD组)和42例稳定期COPD(SCOPD)患者(SCOPD组),同时纳入30例健康体检者作为对照组。检测3组受试者血清NGFR、降钙素原(PCT)、超敏C反应蛋白(hs⁃CRP)、白细胞介素(IL)⁃6水平并进行比较。对两组COPD患者行肺功能检查及CAT评分、BODE指数评估。采用Pearson相关分析探讨COPD患者血清NGFR水平与第1秒用力呼气容积(FEV1)/用力肺活量(FVC)、血清PCT、hs⁃CRP、IL⁃6、CAT评分及BODE指数的关系。结果SCOPD组和AECOPD组患者血清NGFR、PCT、hs⁃CRP、IL⁃6水平均高于对照组,且AECOPD组患者上述指标均高于SCOPD组患者(P<0.05)。AECOPD组患者FEV1/FVC低于SCOPD组,CAT评分和BODE指数均高于SCOPD组患者(P<0.05)。Pearson相关分析结果显示,COPD患者血清NGFR水平与PCT、hs⁃CRP、IL⁃6、CAT评分、BODE指数均呈正相关,而与FEV1/FVC呈负相关(P<0.05)。结论COPD患者血清NGFR水平升高,且与CAT评分、BODE指数均呈正相关,在一定程度上可反映COPD患者的疾病严重程度和炎症反应程度。Objective To explore the expression level of serum nerve growth factor receptor(NGFR)and its correlation with chronic obstructive pulmonary disease(COPD)assessment test(CAT)score and BODE index in patients with COPD.Methods A total of 96 patients with COPD were enrolled,including 54 cases COPD at acute exacerbation(AECOPD)as AECOPD group and 42 cases COPD at stable stage(SCOPD)as SCOPD group.30 healthy subjects were recruited as control group.Serum NGFR,procalcitonin(PCT),high sensitivity C⁃reactive protein(hs⁃CRP)and interleukin(IL)⁃6 levels were detected and compared.Pulmonary function test,CAT score and BODE index evaluation were performed of COPD patients of two groups.Pearson correlation analysis was used to evaluate the relationship among serum NGFR level and forced expiratory volume in the first second(FEV1)/forced vital capacity(FVC),serum PCT,hs⁃CRP,IL⁃6,CAT score and BODE index.Results Serum NGFR,PCT,hs⁃CRP,IL⁃6 in AECOPD group and SCOPD group were both higher than those in control group,and above indexes in AECOPD group were both higher than those in SCOPD group(P<0.05).FEV1/FVC in AECOPD group was lower than that in SCOPD group,CAT score and BODE index were both higher than those in SCOPD group(P<0.05).Pearson correlation analysis showed that serum NGFR level was positively correlated with PCT,hs⁃CRP,IL⁃6,CAT score and BODE index,while was negatively correlated with FEV1/FVC(P<0.05).Conclusion Serum NGFR level significantly increases in patients with COPD and is positively correlated with CAT scores and BODE index,which would reflect the severity of patients with COPD and inflammation degree.

关 键 词：慢性阻塞性肺疾病 神经生长素受体 慢性阻塞性肺疾病评估测试 BODE指数 

分 类 号：R563.3[医药卫生—呼吸系统]