心房颤动易感基因的研究进展  

Research Progress in Susceptible Genes of Atrial Fibrillation

作　　者：周尚蓉 何凤珍 陈宇晴 蔡键 班青丽 刘莉 潘兴寿[2] ZHOU Shangrong;HE Fengzhen;CHEN Yuqing;CAI Jian;BAN Qingli;LIU Li;PAN Xingshou(Youjiang Medical University for Nationalities,Baise 533000,China;Department of Cardiology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院,广西百色533000 [2]右江民族医学院附属医院心血管内科,广西百色533000

出　　处：《医学综述》2021年第4期648-652,共5页Medical Recapitulate

基　　金：国家自然科学基金(81560076);右江民族医学院博士引进科研启动课题项目(yy2015bsky02)。

摘　　要：心房颤动(AF)是最常见的因心房不协调活动而导致的恶性心律失常,目前其发病机制尚未完全明确,现有治疗手段效果欠佳。全基因组关联研究发布了与AF相关的易感基因,包括细胞结构蛋白基因、离子通道基因、转录因子基因、细胞信号转导蛋白基因等,通过研究这些基因的单核苷酸多态性或敲除相关易感基因位点可诱发AF,表明AF在基因层面的研究取得进展,这有助于临床科研工作者从分子生物学层面展开进一步研究和探索,有助于临床进一步完善相关易感基因的检测项目,推动研发针对易感基因的靶向药物,为AF的诊断和临床治疗提供新思路。Atrial fibrillation(AF)is the most common malignant arrhythmia caused by uncoordinated atrial movement.At present,the pathogenesis of this disease is not completely clear,and the existing treatment methods are unsatisfactory.Genome-wide association studies(GWAS)have released susceptible genes related to AF,including cell structural protein genes,ion channel genes,transcription factor genes,cell signal transduction protein genes and so on.The study on these genes has discovered that single nucleotide polymorphisms or knockout-related susceptible loci of these genes may induce AF,indicating that new progress has been made in human research on AF at the genetic level,which is helpful for clinical researchers to carry out further research and exploration from the level of molecular biology,to further improve the test items of related susceptible genes,promote the development of targeted drugs for susceptible genes,and provide new ideas for the diagnosis and clinical treatment of AF.

关 键 词：心房颤动 易感基因 单核苷酸多态性 离子通道基因 转录因子基因 细胞信号转导蛋白基因 

分 类 号：R541.75[医药卫生—心血管疾病]