新生儿高胆红素血症病因的研究进展  

Research Progress in Etiology of Neonatal Hyperbilirubinemia

作　　者：黄家虎 孙建华[1] HUANG Jiahu;SUN Jianhua(Neonatal Intensive Care Unit,Shanghai Children′s Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心新生儿重症监护室,上海200127

出　　处：《医学综述》2021年第4期680-684,共5页Medical Recapitulate

摘　　要：新生儿高胆红素血症(NHB)的发病因素较复杂,包括早产、胎膜早破、感染、尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)基因突变、母乳性黄疸、葡萄糖-6-磷酸脱氢酶(G-6-PD)基因突变等多方面,如果治疗不及时易导致胆红素脑病,损害患儿的神经发育,严重威胁患儿身心健康。以往的研究仅对围生或感染等某一方面进行分析,存在局限性。因此,需要对NHB的发病原因进行多方面探究,以明确NHB的发病因素,为NHB的早期治疗与预防提供依据,降低NHB的发生率。The pathogenesis of neonatal hyperbilirubinemia(NHB)is complicated,including various aspects such as premature labor,premature rupture of membranes,infection,uridine diphosphate glucuronyl transferase 1A1(UGT1A1)gene mutation,breast milk jaundice,glucose-6-phosphate dehydrogenase(G-6-PD)gene mutation,etc.If it is not treated in time,it would easily lead to bilirubin encephalopathy,damage the nerve development of the infants,and seriously threaten their physical and mental health.Previous studies have only analyzed one aspect of perinatal or infection,which has limitations,so it is necessary to explore the various aspects of the causes of NHB in order to clarify the onset factors of NHB and provide a basis for the early treatment and prevention of the disease,so as to reduce the incidence of NHB.

关 键 词：高胆红素血症 围生因素 感染 尿苷二磷酸葡萄糖醛酸转移酶1A1 葡萄糖-6-磷酸脱氢酶 

分 类 号：R722.1[医药卫生—儿科]