急性心肌梗死患者直接PCI后无复流的研究进展  

Research Progress of No-reflow after Direct PCI in Patients with Acute Myocardial Infarction

作　　者：殷宁 宋莉 陆迎爱 牛利利 杨秋荣[1] 宫艳艳 庄娜[1] YIN Ning;SONG Li;LU Yingai;NIU Lili;YANG Qiurong;GONG Yanyan;ZHUANG Na(Department of Cardiology,Lianyungang Second People′s Hospital/Lianyungang Cancer Hospital,Lianyungang 222023,China)

机构地区：[1]连云港市第二人民医院连云港市肿瘤医院心内科,江苏连云港222023

出　　处：《医学综述》2021年第4期743-747,共5页Medical Recapitulate

基　　金：南京医科大学康达学院科研发展基金(KD2019KYJJYB021)。

摘　　要：急性心肌梗死(AMI)起病急,而实施直接经皮冠状动脉介入术(PCI)可降低患者死亡率及预后风险。随着医疗水平的进步,直接PCI治疗AMI成功率升高,但仍有部分患者术后无复流,可进一步加重患者预后风险,有一定院内致死率。PCI后无复流的发生与血管内皮功能、心肌微循环障碍等机制有关,但其确切机制尚未明确。未来应对AMI患者直接PCI后无复流的发生机制进行深入探讨,进一步制订预防及诊治措施,以提高AMI患者直接PCI治疗的成功率,降低患者预后风险。Acute myocardial infarction(AMI)has a sudden onset,and the implementation of direct percutaneous coronary intervention(PCI)can reduce mortality and prognostic risks of the patients.With the advancement of medical level,the success rate of direct PCI in the treatment of AMI has increased,but there are still some patients without reflow after surgery,which can further aggravate the prognostic risk of the patients and has a certain hospital mortality rate.The occurrence of no-reflow after PCI is related to mechanisms such as vascular endothelial function and myocardial microcirculation disorder,but its exact mechanism is not yet clear.In the future,it is necessary to conduct an in-depth discussion on the mechanism of no-reflow in AMI patients after direct PCI,and make prevention and diagnosis and treatment measures,in order to improve the success rate of direct PCI and reduce the prognostic risk.

关 键 词：急性心肌梗死 经皮冠状动脉介入术 无复流 内皮功能障碍 心肌微循环障碍 微血管远端栓塞 

分 类 号：R542.22[医药卫生—心血管疾病]