鱼油脂肪乳制剂治疗肠衰竭相关性肝病的研究现状  

Current status on treatment of intestinal failure-associated liver disease by fish oil lipid emulsion

作　　者：马忠扬 王浩然 岳艳 张莉 母得志 Ma Zhongyang;Wang Haoran;Yue Yan;Zhang Li;Mu Dezhi(Department of Pediatrics,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China;West China School of Medicine,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041 [2]四川大学华西临床医学院,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2020年第6期641-646,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金项目(81630038、81971433)。

摘　　要：肠外营养(PN)是维持肠道功能障碍患儿生命的重要手段。但是,若患儿长期依赖PN,则可能导致严重并发症,如肠衰竭相关性肝病(IFALD)等。脂肪乳是PN制剂的重要组成成分。研究表明,第1代脂肪乳制剂(豆油脂肪乳制剂)是导致IFALD发生的原因之一,而第4代脂肪乳制剂(鱼油脂肪乳制剂)不仅无此不良反应,而且还可用于IFALD治疗。笔者拟对目前鱼油脂肪乳制剂治疗IFALD的有效性及安全性的研究现状进行阐述,旨在为临床对PN患儿的脂肪乳制剂选择提供参考。Parenteral nutrition(PN)is an important measure to maintain the life of children with intestinal dysfunction.However,long-term dependence on PN may lead to serious complications,such as intestinal failure-associated liver disease(IFALD).Lipid emulsion is one of important components of PN.Studies have shown that the first generation of lipid emulsion(soybean oil lipid emulsion)is one of the causes of IFALD.While the fourth generation of lipid emulsion(fish oil lipid emulsion)not only has no this side effect,but also could be used for treatment of IFALD.This paper summarizes the recent studies on the efficacy and safety of fish oil lipid emulsion in treatment of IFALD,in order to provide evidences for clinical application of fish oil lipid emulsion.

关 键 词：鱼油 脂肪乳剂 静脉注射用 胃肠外营养 肠衰竭相关性肝病 儿童 

分 类 号：R725.7[医药卫生—儿科]