Negative conversion of autoantibody profile in chronic hepatitis B:A case report  

作　　者：Xun Zhang Qin-Xiu Xie Dong-Mei Zhao 

机构地区：[1]Department of Infectious Disease,The Fourth Affiliated Hospital of Anhui Medical University,Hefei 230012,Anhui Province,China [2]Department of Infectious Disease,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui Province,China

出　　处：《World Journal of Clinical Cases》2021年第5期1196-1203,共8页世界临床病例杂志

摘　　要：BACKGROUND Autoimmune antibodies are detected in many diseases.Viral infections are accompanied by several immunopathological manifestations.Some autoimmune antibodies have been associated with the immune response induced by virus or drugs.Thus,a comprehensive diagnosis of chronic hepatitis B combined with autoimmune hepatitis is required,and immunosuppressant or antiviral therapy should be carefully considered.CASE SUMMARY We present a case of a patient who had negative transformation of autoimmune antibodies during chronic active hepatitis B.A 50-year-old female who had a history of asymptomatic hepatitis B virus carriers for more than 10 years presented to the hospital with the complaint of weakness for 1 wk.Blood tests revealed elevated liver enzymes;the detection of autoantibodies was positive.Hepatitis B viral load was 72100000 IU/mL.The patient started tenofovir alafenamide fumigate 25 mg daily.Liver biopsy was performed,which was consistent with chronic active hepatitis B.The final diagnosis of the case was chronic active hepatitis B.The autoimmune antibodies turned negative after 4 wk of antiviral therapy.The patient recovered and was discharged with normal liver function.There was no appearance of autoantibodies,and liver function was normal at regular follow-ups.CONCLUSION Autoimmune antibodies may appear in patients with chronic active hepatitis.It is necessary to differentiate the diagnosis with autoimmune hepatitis.

关 键 词：AUTOANTIBODIES Autoimmune hepatitis Chronic hepatitis B Immune responses Case report 

分 类 号：R512.62[医药卫生—内科学]