Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways  

作　　者：Mushtaq Ahmad Ansari Mohammad Raish Yousef A Bin Jardan Ajaz Ahmad Mudassar Shahid SheikhFayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet 

机构地区：[1]Department of Pharmacology and Toxicology,College of Pharmacy,King Saud University,Riyadh 11451,Saudi Arabia [2]Department of Pharmaceutics,College of Pharmacy,King Saud University,Riyadh 11451,Saudi Arabia [3]Department of Clinical Pharmacy,College of Pharmacy,King Saud University,Riyadh 11451,Saudi Arabia

出　　处：《World Journal of Gastroenterology》2021年第7期592-608,共17页世界胃肠病学杂志（英文版）

基　　金：Deanship of Scientific Research at King Saud University,No.RG-1439-083.

摘　　要：BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer activities.Its mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue injuries.AIM To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in rats.METHODS Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal saline.SA was administered orally once daily starting 7 d before LPS/D-GalN treatment.RESULTS Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model rats.However,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway.CONCLUSION In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB.

关 键 词：Sinapic acid D-galactosamine/lipopolysaccharide Oxidative stress Fulminant hepatitis ANTIOXIDANT Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways 

分 类 号：R285[医药卫生—中药学]