Mononeuropathy multiplex associated with systemic vasculitis:A case report  

作　　者：Hyun Jun Chae Jung Woo Kim Yae Lim Lee Jeong Hwan Park Sang Yoon Lee 

机构地区：[1]Department of Rehabilitation Medicine,Seoul National University College of Medicine,Seoul National University Hospital,Seoul 07061,South Korea [2]Department of Pathology,Seoul National University College of Medicine,SMG-SNU Boramae Medical Center,Seoul 07061,South Korea [3]Department of Rehabilitation Medicine,Seoul National University College of Medicine,SMG-SNU Boramae Medical Center,Seoul 07061,South Korea

出　　处：《World Journal of Clinical Cases》2021年第7期1741-1747,共7页世界临床病例杂志

摘　　要：BACKGROUND Vasculitis,a systemic disorder with inflammation of blood vessel walls,can develop broad spectrum of signs and symptoms according to involvement of various organs,and therefore,early diagnosis of vasculitis is challenging.We herein describe a patient who developed a special case of systemic vasculitis with mononeuropathy multiplex,rectal perforation and antiphospholipid syndrome(APS)presented with pulmonary embolism.CASE SUMMARY A 61-year-old woman visited hospital with complaints of myalgia and occasional fever.She was initially diagnosed as proctitis and treated with antibiotics,however,there was no improvement.In addition,she also complained right foot drop with hypesthesia,and left 2^(nd) and 3^(rd) finger tingling sensation.She underwent nerve conduction study for evaluation,and it revealed sensorimotor polyneuropathy in the left arm and bilateral legs.Subsequent sural nerve biopsy strongly suggested vasculitic neuropathy.Based on nerve biopsy and clinical manifestation,she was diagnosed with vasculitis and treated with immunosuppressive therapy.During treatment,sudden rectal perforation and pulmonary thromboembolism occurred,and further laboratory study suggested probable concomitant APS.Emergency Hartmann operation was performed for rectal perforation,and anti-coagulation therapy was started for APS.After few cycles of immunosuppressive therapy,tingling sensation and weakness in her hand and foot had been partially recovered and vasculitis was considered to be stationary.CONCLUSION Vasculitis can be presented with a variety of signs and symptoms,therefore,clinicians should always consider the possibility of diagnosis.

关 键 词：Systemic Vasculitis Peripheral nervous system diseases MONONEUROPATHIES Antiphospholipid syndrome Pulmonary embolism Case report 

分 类 号：R593.2[医药卫生—内科学] R747.9[医药卫生—临床医学]