基于RTOG 0813剂量学标准比较网格设定大小对NSCLC立体定向放射治疗计划的影响  

Effect of Dose Grid Size According to RTOG 0813 Protocol Treatment Planning Guidelines in Early-stage Non-small Lung Cancer Stereotactic Radiation Therapy

作　　者：徐玥靓 涂彧[1] XU Yueliang;TU Yu(School of Radiation Medicine and Protection,Soochow University,Suzhou 215123,China;Affiliated First Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]苏州大学医学部放射医学与防护学院,江苏苏州215123 [2]苏州大学附属第一医院,江苏苏州215006

出　　处：《北华大学学报（自然科学版）》2021年第1期69-74,共6页Journal of Beihua University（Natural Science）

基　　金：江苏省自然科学基金项目(BK20181086).

摘　　要：目的应用肿瘤放射治疗组(RTOG)0813协议规定的剂量学参数,比较分析不同大小网格设定对早期非小细胞肺癌(Non-small cell lung cancer,NSCLC)立体定向放射治疗(SBRT)计划的影响.方法选取13例NSCLC患者,将制定的SBRT放疗计划结果用1、2、3、4 mm网格采用AAA算法分别计算最终剂量.以1 mm网格计划作为参考,与2~4 mm网格计划进行比较,参数包括R100%、R50%、D2 cm、V20,并根据计划靶区(PTV)的体积将偏差分为小偏差和大偏差,同时比较4种网格计划在机器跳数(MU)、计算时间和γ通过率的差异.结果根据RTOG 0813报告,所有计划未出现大偏差,均能符合其剂量学标准.报告参数方面,与1 mm网格计划相比,除了2 mm计划的R100%差异无统计学意义外,其余差异均具有统计学意义(P<0.05);在计算时间上,网格越大,耗时越少,差异具有统计学意义(P<0.05);在机器跳数上,网格越小,跳数越少,且差异具有统计学意义(P<0.05);在γ通过率方面,网格越小,通过率越高,差异具有统计学意义(P<0.05).结论在SBRT计划治疗中,1 mm网格精度计划适形度最佳,且有更高的剂量衰减梯度.Objective To compare and analyze the effect of different grid size settings on the stereotactic body radiation therapy(SBRT)plans for early-stage non-small cell lung cancer(NSCLC)with the dosimetric parameters specified in 0813 protocol of the radio therapy oncology group(RTOG),and to provide a reference for the clinical design of lung SBRT plan in the selection of grid size.Method Thirteen cases with NSCLC were selected,and the final dose was calculated by using 1,2,3 and 4 mm grids for the SBRT radiotherapy plan.1 mm grid plan as reference compares with 2~4 mm grid size plans,including R100%,R50%,D2 cm,V20,deviations were classified as minor and major according to the volume of PTV,and comparing four kinds of grid plans in monitor units(MU),the computation time and differences of gamma pass rate.Results According to the RTOG 0813 report,no major deviations were observed in all the plans and all were dosimetric.In terms of the report parameters,compared with the 1mm grid plan,all the differences were statistically significant(P<0.05),except for R100%of the 2 mm grid plan.In terms of the computing time,the larger the grid was,the less time consumption,and the difference was statistically significant(P<0.05).In terms of the monitor units,the smaller the grid size was,the fewer MU,and the difference was statistically significant(P<0.05).In terms of the gamma pass rate,the smaller the grid size was,the higher the pass rate was,and the difference was also statistically significant(P<0.05).Conclusion In the SBRT treatment,1 mm grid plan has the best conformal and higher dose attenuation gradient.

关 键 词：网格精度 立体定向放射治疗 早期非小细胞肺癌 RTOG 0813 

分 类 号：R811.1[医药卫生—放射医学]