Multifunctional shape-dependent plasmonic nanoprobe by enzymatic etching of single gold triangular nanoplate  

作　　者：Ning Feng Jingjing Shen Yu Chen Chang Li Yanling Hu Lei Zhang Shufen Chen Quli Fan Wei Huang Lianhui Wang 

机构地区：[1]Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials(IAM),Nanjing University of Posts and Telecommunications,9 Wenyuan Road,Nanjing,210023,China [2]School of Electrical and Control,Nanjing Polytechnic Institute,188 Xinle Road,Nanjing,211500,China [3]Frontiers Science Center for Flexible Electronics(FSCFE),Shaanxi Institute of Flexible Electronics(SIFE)and Shaanxi Institute of Biomedical Materials and Engineering(SIBME),Northwestern Polytechnical University(NPU),127 West Youyi Road,Xi’an,710072,China

出　　处：《Nano Research》2020年第12期3364-3370,共7页纳米研究（英文版）

基　　金：This work was financially supported by the National Key Research and Development Program of China(No.2017YFA0205302);the National Natural Science Foundation of China(Nos.61571239 and 21674048);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R37);the Key Research and Development Program of Jiangsu(No.BE2018732).

摘　　要：Hydrogen peroxide(H2O2),as a signaling molecule,plays a vital role in a wide variety of signaling transduction processes,aging,and diseases.However,the excessive production of H2O2 causes various diseases.Herein,we develop a novel method for H2O2 detection in live cells via dark-field scattering spectroscopy with gold triangular nanoprisms(AuTNPs)as probes.The corners of AuTNPs would be gradually oxidatively etched by the strong coordination of Br•which is generated by enzymatic reactions in the presence of horseradish peroxidase(HRP),bromide ion and trace hydrogen peroxide.Benefitting from the morphological change,the single AuTNP based plasmonic nanoprobe shows notable blueshifts and scattering color changes which could be real-time monitored under the dark-field microscopy.The peak position in the scattering spectra of individual AuTNP blueshifts linearly with the increase of H2O2 concentration,and exhibits high sensitivity to H2O2 in a large range from 2.5 to 100µM with a low detection limit(LOD)of 0.74µM.Moreover,the experimental results were supported by the simulated results via the finite-difference time-domain(FDTD)method.The nanoprobes have been further used for intracellular H2O2 detection in live cells.Besides,the etching of AuTNP also provides an alternative method to design novel plasmonic logic chips and write-once plasmonic memories.

关 键 词：gold triangular nanoprisms enzymatic etching PLASMONIC H2O2 detection logic operations 

分 类 号：O53[理学—等离子体物理]