Electrostatic assembly functionalization of poly(γ-glutamic acid)for biomedical antibacterial applications  

作　　者：Xiaodan Wang Hengchong Shi Haoyu Tang Huan Yu Qiuyan Yan Huawei Yang Xu Zhang Shifang Luan 

机构地区：[1]State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]University of Science and Technology of China,Hefei 230026,China [3]Institute of Functional Nano&Soft Materials,Soochow University,Suzhou 215123,China

出　　处：《Journal of Materials Science & Technology》2020年第24期14-25,共12页材料科学技术（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.51973221 and 51873213);the Youth Innovation Promotion Association of CAS(No.2017269);the Major Science and Technology Innovation Project of Shandong Province(No.2019JZZY011105);the High-Tech Research&Development Program of CAS-WEGO Group。

摘　　要：Poly(γ-glutamic acid)(γ-PGA)has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate(ELA).The functionalized γ-PGA compound(γ-PGA-ELA)ethanol solution can facilely produce colorless and transparent coatings on various inorganic,metal,and polymeric substrates,especially for the lumen of slender catheters(length up to 2 m,and inner diameter down to 1 mm).The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo.In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion,and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy.More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility,low cytotoxicity,and satisfactory histocompatibility.The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections.

关 键 词：Functionalized poly(γ-glutamic acid)compound Electrostatic assembly Antibacterial coating Antibacterial additive Catheter-associated infections 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317[医药卫生—基础医学] O641.3[化学工程—高聚物工业]