胚胎停育妇女宫颈支原体感染流行病学及耐药性  

Epidemiology and drug resistance of cervical mycoplasma infection in women with embryo developmental arrest

作　　者：史俊青 韩丰娟 薛格艳 张峰琴 张小学[4] SHI Jun-qing;HAN Feng-juan;XUE Ge-yan;ZHANG Feng-qin;ZHANG Xiao-xue(Yuncheng Vocational College of Nursing,Yuncheng,Shanxi 044000,China;不详)

机构地区：[1]运城护理职业学院儿科,山西运城044000 [2]运城市第二医院临床检验科,山西运城044000 [3]运城护理职业学院妇科,山西运城044000 [4]山西省儿童医院小儿外科,山西太原030000

出　　处：《中华医院感染学杂志》2020年第24期3783-3787,共5页Chinese Journal of Nosocomiology

基　　金：运城护理职业学院科研立项资助项目(2019001)。

摘　　要：目的分析胚胎停育妇女宫颈支原体感染流行病学与影响因素及耐药性情况。方法回顾性分析运城市第二医院2015年1月-2019年12月收治的经B超确诊为胚胎停育并接受宫颈支原体分离培养检查的200例妇女的临床资料,分析宫颈支原体感染的流行病学特征及耐药性,并采用多因素Logistic回归分析胚胎停育妇女宫颈支原体感染的影响因素。结果200例胚胎停育妇女中有86例检出支原体感染,感染率为43.00%,以单一解脲支原体(Uu)为主占59.30%(51/86),在21~30岁年龄段、服务业从事者、中学以下教育程度、春夏季的感染率较高,同时胚胎停育次数越多支原体感染率也越高,并且5年来的支原体感染率呈递增趋势;药敏试验结果显示:Uu、人型支原体(Mh)、Uu+Mh 3种感染类型对喹诺酮类抗菌药的耐药性较高,并且Uu+Mh混合感染的耐药性要高于Uu感染,3种感染类型均对交沙霉素、原始霉素、强力霉素敏感(耐药率≤10%);多因素Logistic回归分析结果显示:年龄(OR=2.113、95%CI:1.140~3.917)、流产次数(OR=2.951、95%CI:1.426~6.105)、宫颈上皮柱状改变(OR=2.195、95%CI:1.214~3.967)、既往生殖道感染史(OR=1.872、95%CI:1.131~3.098)、不洁性接触史(OR=2.450、95%CI:1.332~4.507)、丈夫支原体感染史(OR=1.960、95%CI:1.037~3.706)是胚胎停育妇女宫颈支原体感染的影响因素(P<0.05)。结论增强支原体宣传教育并在孕前进行支原体感染检查对降低胚胎停育发生有积极意义。OBJECTIVE To analyze the epidemiology,influencing factors and drug resistance of cervical mycoplasma infection in women with embryo growth arrest.METHODS A retrospective analysis was performed on the clinical data of 200 women who were confirmed embryo developmental arrest by B-ultrasound and tested for cervical mycoplasma contamination in Yuncheng Second Hospital from January 2015 to December 2019.The epidemiology features and drug resistance of cervical mycoplasma infection were analyzed.The risk factors of cervical mycoplasma infection in women with embryo developmental arrest were analyzed by multivariate logistic regression analysis.RESULTS Of the 200 women with embryo growth arrest,86 cases(43.00%)were with mycoplasma infection,mainly on single Ureaplasma urealyticum(Uu)accounting for 59.30%(51/86).The infection rates were relatively higher in patients aged 21-30 years old,with service industry occupation,with education below middle school,and in spring and summer.The higher incidence of embryo growth arrest accompanied by the higher the infection rate of mycoplasma,and the infection rate of mycoplasma had shown increasing trend in the past 5 years.The results of drug susceptibility tests showed that drug resistance rate of Uu,Mycoplasma hominis(Mh)and Uu+Mh to quinolone antibacterials were relatively higher.The drug resistance of Uu+Mh infection was higher than that of Uu infection.Strains in the three types of infection were sensitive to josamycin,pristinamycin and doxycycline(drug resistance rate≤10%).Multivariate logistic regression analysis showed that age(OR=2.113,95%CI:1.140-3.917),times of abortion(OR=2.951,95%CI:1.426-6.105),cervical erosion(OR=2.195,95%CI:1.214-3.967),previous history of reproductive tract infection(OR=1.872,95%CI:1.131-3.098),unclean sexual contact(OR=2.450,95%CI:1.332-4.507)and mycoplasma infection history in husband(OR=1.960,95%CI:1.037-3.706)were independent risk factors of cervical mycoplasma infection in women with embryo growth arrest(P<0.05).CONCLUSION Publicity educatio

关 键 词：胚胎停育 支原体感染 流行病学 危险因素 耐药性 

分 类 号：R518.9[医药卫生—内科学]