液基薄层细胞学和人乳头瘤病毒联合DNA倍体分析在宫颈癌筛查中的结果分析  

Combination of thinprep cytologic test,human papillomavirus and DNA ploidy analysis in cervical cancer screening

作　　者：林燕蝶 李至睿 李红霞[1] 李静[1] 邢宜 孙赫男 朱红艳 刘爱军[1] LIN Yan-die;LI Zhi-rui;LI Hong-xia;LI Jing;XING Yi;SUN He-nan;ZHU Hong-yan;LIU Ai-jun(Department of Pathology,the Seventh Medical Center of PLA General Hospital,Beijing100900,China;Department of Stomatology,the First Medical Center of PLA General Hospital,Beijing 100039,China)

机构地区：[1]解放军总医院第七医学中心病理科,北京100900 [2]解放军总医院第一医学中心口腔科,北京100039

出　　处：《诊断病理学杂志》2020年第12期881-884,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的研究人乳头状瘤病毒(HPV)感染与宫颈脱落细胞DNA倍体分析联合液基细胞学检测(TCT)对宫颈癌早期筛查的临床意义,并探讨三种检测结果的年龄差异性。方法随机抽取2019—2020年在解放军总医院第七医学中心妇科检查的2300例患者为研究对象,均行HPV、DNA倍体分析及TCT联合检测,128名患者宫颈组织活检用于确定诊断及比较分析。结果2300例患者中HPV检测、DNA倍体分析及TCT检测检出率分别为16.6%、15.04%及5.96%,不同年龄组阳性率比较HPV检测无统计学差异(P=0.05),但DNA倍体分析、TCT检测结果在不同年龄组具有统计学差异(P<0.05)。以病理活检结果作为金标准,HPV检测、DNA倍体分析及TCT检测灵敏性分别为92.68%、79.27%、64.63%,特异性分别为21.73%、47.83%、63.04%,差异具有统计学意义(P<0.05)。结论随着年龄增加,易造成DNA倍体分析及TCT检测异常,三种检测方法在宫颈癌筛查中,HPV检测灵敏性最高,TCT检测特异性最高。Objective To assess the clinical value of human papillomavirus(HPV)test,DNA ploidy analysis and thinprep cytologyic test(TCT)results in cervical cancer screening and to explore the difference in age trends in the three methods.Methods From 2019 to 2020,a total of 2300 cases undergoing HPV test,DNA ploidy analysis and TCT in the 7thMedical Center of PLA Central Hospital were enrolled in this study.128 cases were assessed with the pathological results of biopsy samples as diagnosis and comparative analysis.Results Among the tested 2300 patients,the positive rate of HPV test,DNA ploidy analysis and TCT was 16.6%,15.04%and 5.96%;the HPV test was no significant differences in positive rates among different age groups(P=0.05),but the positive rates of DNA ploidy analysis and TCT in different age groups were statistically significant(P<0.05).Taking pathological result as the gold standard,comparision with HPV test,DNA ploidy analysis and TCT,the sensitivity was 92.68%,79.27%and 64.63%respectively,the specificity was 21.73%,47.83%and 63.04%respectively.Conclusion There is prone to DNA ploidy and TCT abnormalities along with the growth of the age.Among the three tests,the HPV test is the most sensitivity for screening for cervical cancer,and the TCT shows the most results in specificity.

关 键 词：HPV检测 DNA倍体分析 TCT检测 宫颈癌 年龄 

分 类 号：R446.82[医药卫生—诊断学] R737.3[医药卫生—临床医学]