Contradictory effect of gold nanoparticle-decorated molybdenum sulfide nanocomposites on amyloid-β-40 aggregation  

作　　者：Yaqin Liu Yan Zheng Shaoyuan Li Jinhan Li Xiaoyu Du Yanyun Ma Guofu Liao Qing Wang Xiaohai Yang Kemin Wang 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Cchemistry and Chemical Enginerng,Key Laboratory for Bio-Nanotchmrology and Molecular Engineering of Hunan Province,Hunan University,Changsha 410082,China

出　　处：《Chinese Chemical Letters》2020年第12期3113-3116,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21375034,21675047 and 21735002);Natural Science Foundation for Distinguished Young Scholars of Hunan Province(No.2016JJ1008)。

摘　　要：The effect of gold nanoparticle-decorated molybdenum sulfide(AuNP-MoS2)nanocomposites on amyloid-β-40(Aβ40)aggregation was investigated.The interesting discovery was that the effect of AuNPMoS2 nanocomposites on Aβ40 aggregation was contradictory.Low concentration of AuNP-MoS2 nanocomposites could enhance the nucleus formation of Aβ40 peptides and accelerate Aβ40 fibrils aggregation.However,although high concentration of AuNP-MoS2 nanocomposites could enhance the nucleus formation of Aβ40 peptides,it eventually inhibited Aβ40 aggregation process.It might be attributed to the interaction between AuNP-MoS2 nanocomposites and Aβ40 peptides.For low concentration of AuNP-MoS2 nanocomposites,it was acted as nuclei,resulting in the acceleration of the nucleation process.However,the structural flexibility of Aβ40 peptides was limited as the concentration of AuNP-MoS2 nanocomposites was increased,resulting in the inhibition of Aβ40aggregation.These findings suggested that AuNP-MoS2 nanocomposites might have a great potential to design new multifunctional material for future treatment of amyloid-related diseases.

关 键 词：Amyloid peptides Gold nanoparticle-decorated molybdenum SULFIDE Inhibition ACCELERATION Atomic force microscopy 

分 类 号：R318.08[医药卫生—生物医学工程] TB33[医药卫生—基础医学]