NIR-triggered drug delivery system based on phospholipid coated ordered mesoporous carbon for synergistic chemo-photothermal therapy of cancer cells  

作　　者：Anman Zhang Luo Hai Tianzheng Wang Hong Cheng Man Li Xiaoxiao He Kemin Wang 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Biology,Collere of chemistry and Chemical Engineerig,Hunan Uiverity ste keyLaboratory for Bic-Nanotechnology and Molecular Engineering of Hunan Province,Chargsha 410082,China

出　　处：《Chinese Chemical Letters》2020年第12期3158-3162,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21735002,21521063,21675046,21874035,21806186 and 21775036);the Natural Science Foundation of Hunan Province,China(No.2018JJ2033);the Key Point Research and Invention Program of Hunan Province,China(No.2017DK2011)。

摘　　要：Chemo-photothermal treatment is one of the most efficient strategies for cancer therapy.However,traditional drug carriers without near-infrared absorption capacity need to be loaded with materials behaving photothermal properties,as it results in complicated synthesis process,inefficient photothermal effects and hindered NIR-mediated drug release.Herein we report a facile synthesis of a polyethylene glycol(PEG)linked liposome(PEG-liposomes)coated doxorubicin(DOX)-loaded ordered mesoporous carbon(OMC)nanocomponents(PEG-LIP@OMC/DOX)by simply sonicating DOX and OMC in PEG-liposomes suspensions.The as-obtained PEG-LIP@OMC/DOX exhibits a nanoscale size(600±15 nm),a negative surface potential(-36.70 mV),high drug loading(131.590 mg/g OMC),and excellent photothermal properties.The PEG-LIP@OMC/DOX can deliver loaded DOX to human MCF-7 breast cancer cells(MCF-7)and the cell toxicity viability shows that DOX unloaded PEG-LIP@OMC has no cytotoxicity,confirming the PEG-LIP@OMC itself has excellent biocompatibility.The NIR-triggered release studies demonstrate that this NIR-responsive drug delivery system enables on-demand drug release.Furthermore,cell viability results using human MCF-7 cells demonstrated that the combination of NIR-based hyperthermal therapy and triggered chemothe rapy can provide higher therapeutic efficacy than re spective monothe rapies.With these excellent features,we believe that this phospholipid coating based multifunctional delivery system strategy should promote the application of OMC in nanomedical applications.

关 键 词：Ordered mesoporous carbon Polyethylene glycol linked liposomes Stimuli-responsive drug delivery system NIR-triggered drug delivery Chemo-photothermal therapy 

分 类 号：R943[医药卫生—药剂学] TQ460.4[医药卫生—药学]