Ultrasound-assisted tandem synthesis of tri-and tetra-substituted pyrrole-2-carbonitriles from alkenes,TMSCN and N,N-disubstituted formamides  

作　　者：Qing-Wen Gui Fan Teng Sheng-Neng Ying Yang Liu Tao Guo Jian-Xin Tang Jin-Yang Chen Zhong Cao Wei-Min He 

机构地区：[1]College of Chemistry and Materials Science,Hunan Agricultural University,Changsha 410128,China [2]School of Life Scienices and Chenistry,Hunan University of Technology,zhuzhou 412007,China [3]Hunan Provincial Key Laboratory of Materials Protection for Flectric Power and Tramnsportation,Changsha Univerity of Sciene and Technology,Changsha 410114,China

出　　处：《Chinese Chemical Letters》2020年第12期3241-3244,共4页中国化学快报（英文版）

基　　金：the Hunan Provincial Natural Science Foundation of China(Nos.2018JJ3215 and 2019JJ20008);the Research Foundation of Education Bureau of Hunan Province(No.18C0147);Double first-class construction project of Hunan Agricultural University(No.SYL2019064)。

摘　　要：An energy-saving and eco-friendly method for the efficient construction of various tri-and tetrasubstituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem reaction of readily available alkenes,TMSCN and N,N-disubstituted formamides within 40 min under metal-,solvent-free and mild conditions was developed.The dual role of iodine(catalyst and oxidant)notably simplified the reaction conditions and reduced the chemical waste generated.

关 键 词：Green chemistry Solvent-free Tandem reaction Dual role ULTRASOUND 

分 类 号：TQ226.61[化学工程—有机化工]