IVF-ET治疗中男方HBV与HCV感染对不孕症妇女胚胎发育及妊娠结局的影响  

Effect of HBV and HCV infection in the males on embryo development and pregnancy outcomes of infertility women after IVF-ET

作　　者：纪梦 张小建[2] 李玉涛[1] 彭礼繁 JI Meng;ZHANG Xiao-jian;LI Yu-tao;PENG Li-fan(Sichuan Provincial People’s Hospital(Eastern Branch),Chengdu,Sichuan 610110,China;不详)

机构地区：[1]四川省人民医院(东院)辅助生殖中心,四川成都610110 [2]四川省人民医院妇产科,四川成都610072

出　　处：《中华医院感染学杂志》2020年第23期3664-3667,共4页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金青年基金资助项目(81801423)。

摘　　要：目的探讨体外受精-胚胎移植(In vitro fertilizati embryo transfer,IVF-ET)治疗中男方感染乙型肝炎病毒(Hepatitis B virus,HBV)与丙型肝炎病毒(Hepatitis C virus,HCV)对不孕症妇女胚胎发育、妊娠结局的影响。方法选取2018年2月-2019年2月于四川省人民医院进行IVF-ET治疗中仅男性HBV与HCV感染的104例作为阳性组,另选取同期IVF-ET治疗且双方均未出现HBV与HCV感染的130例作为阴性组,比较两组受精情况、胚胎发育情况以及妊娠结局情况。结果阳性组移植胚胎个数、胚胎评分、正常受精率、卵裂率、优质胚胎率分别为(2.83±0.80)个、(8.57±0.65)分、63.93%、85.52%、61.23%,阴性组分别为(3.01±0.76)个、(8.62±0.67)分、65.89%、87.31%、62.79%,两组胚胎发育差异比较无统计学意义;两组种植率、临床妊娠率、早期流产率、晚期流产率、分娩率以及新生儿畸形情况比较,差异无统计学意义。结论不孕症夫妇在IVF-ET中男性感染HBV、HCV对胚胎发育、妊娠结局影响不明显。OBJECTIVE To explore the effect of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection in the males on embryo development and pregnancy outcomes of infertility women after in vitro fertilization embryo transfer(IVF-ET) process. METHODS During the period from Feb. 2018 to Feb. 2019, 104 infertile couples with husband positive infection of HBV and HCV receiving IVF-ET in Sichuan Provincial People’s Hospital were enrolled as the positive group, and 130 couples with husband negative infection with HBV and HCV during the same period were enrolled as the negative group. The fertilization, embryo development and pregnancy outcomes were compared between the two groups. RESULTS The number of transplanted embryos, embryo score, normal fertilization rate, cleavage rate and high-quality embryo rate in the positive group were(2.83±0.80),(8.57±0.65) points, 63.93%, 85.52% and 61.23%, respectively, and that in the negative group were(3.01±0.76),(8.62±0.67) points, 65.89%, 87.31% and 62.79%, respectively. The difference of embryo development between the two groups was not significant. The implantation rate, clinical pregnancy rate, early abortion rate, late abortion rate and delivery rate in the positive group were 58.22%, 66.35%, 8.70%, 10.14%, 53.84%, and that in the negative group were 56.52%, 70.00%, 6.59%, 5.49%, 61.54%, respectively. There was no significant difference of pregnancy outcomes between the two groups. CONCLUSION The effect of HBV and HCV infection in the males are not significant on embryo development and pregnancy outcome in couples in IVF-ET process.

关 键 词：体外受精-胚胎移植 乙型肝炎病毒 丙型肝炎病毒 胚胎发育 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]