虎杖痛风方治疗急性痛风的疗效及对炎症细胞因子影响  

Efficacy of Polygonum Cuspidatum Gout Prescription on acute gout and its impacts on inflammatory cytokines

作　　者：陈茜[1] 虞斌[2] 王涧[3] 谭又吉[2] 王超霞[4] 王景权[2] CHEN Qian;YU Bin;WANG Jian;TAN Youji;WANG Chaoxia;WANG Jingquan(Department of Clinical Laboratory,Zhejiang Institute of Dermatology Prevention and Treatment,Deqing 313200,China;Department of Gout Clinic,Zhejiang Institute of Dermatology Prevention and Treatment,Deqing 313200,China;DepartmentⅠof Dermatology,Zhejiang Institute of Dermatology Prevention and Treatment,Deqing 313200,China;Nursing Department,Zhejiang Institute of Dermatology Prevention and Treatment,Deqing 313200,China)

机构地区：[1]浙江省皮肤病防治研究所检验科,浙江德清313200 [2]浙江省皮肤病防治研究所痛风门诊,浙江德清313200 [3]浙江省皮肤病防治研究所皮肤一科,浙江德清313200 [4]浙江省皮肤病防治研究所护理部,浙江德清313200

出　　处：《中国现代医生》2021年第1期24-27,共4页China Modern Doctor

基　　金：浙江省医药卫生科研基金项目(2017KY313);浙江省皮肤病医院院级科研项目(2017-10)。

摘　　要：目的探讨虎杖痛风方治疗急性痛风的效果及其对血清炎症细胞因子的影响。方法2017年7月至2019年6月随机选择我院痛风门诊急性痛风患者,分为对照组(B组)和治疗组(A组),对照组给予塞来昔布胶囊0.2 g治疗,bid,治疗组在此基础上加用虎杖痛风方,每天1剂。7 d后观察统计两组临床疗效、疼痛评分(0~10分,视觉模拟评分法VAS)、血清炎症细胞因子水平及不良反应发生情况。结果最终纳入统计的75例对象中A组37例,B组38例,A组痊显率为91.89%(34/37),高于B组的73.68%(28/38),差异有统计学意义(χ^(2)=4.34,P=0.04)。两组治疗前后疼痛评分差异均有统计学意义(P<0.05),其中A组治疗后VAS评分显著低于B组,差异有统计学意义(Z=-2.54,P=0.01)。急性痛风相关炎症细胞因子IL-1β、IL-6、IL-8、TNF-α治疗前后两组均有显著性差异(P<0.05),治疗后的IL-1β、TNF-α水平A组较B组低,差异有统计学意义(P<0.05)。A、B组不良反应均不影响治疗,发生率分别为10.81%(4/37)和5.26%(2/38),差异无统计学意义(χ^(2)=0.78,P=0.38)。结论虎杖痛风方治疗急性痛风效果肯定,可能系通过下调炎症细胞因子IL-1β、TNF-α水平发挥作用。Objective To investigate the efficacy of Polygonum Cuspidatum Gout Prescription on acute gout and its impacts on serum inflammatory cytokines.Methods From July 2017 to June 2019,acute gout patients in gout clinic of our hospital were randomly selected and divided into the control group(group B)and the treatment group(group A).The control group was treated with celecoxib capsule for 0.2 g each time,bid.On this basis,the treatment group was additionally treated with Polygonum Cuspidatum Gout Prescription,one dose each day.Seven days later,clinical efficacy,pain score(0-10,visual analogue scale,VAS),serum inflammatory cytokine level and adverse reactions were observed and counted.Results Of the 75 cases finally included in the statistics,they were divided into group A(n=37)and group B(n=38).The recovery rate of group A was 91.89%(34/37),which was higher than 73.68%(28/38)in group B,with statistical difference(χ^(2)=4.34,P=0.04).The pain scores at baseline and post-treatment were statistically different between the two groups(P<0.05),and the VAS scores of post-treatment in group A were significantly lower than those in group B(Z=-2.54,P=0.01).The levels of acute gout-related inflammatory cytokines IL-1β,IL-6,IL-8 and TNF-αat baseline and post-treatment were significantly different in the two groups(P<0.05).The levels of IL-1βand TNF-αafter treatment in group A were significantly lower than those in group B(P<0.05).The adverse reactions in group A and B did not affect the treatment,and the incidence rates were 10.81%(4/37)and 5.26%(2/38),respectively,with no significant difference(χ^(2)=0.78,P=0.38).Conclusion Polygonum Cuspidatum Gout Prescription has a definite efficacy on acute gout,which plays a role by down-regulating the levels of inflammatory cytokines IL-1βand TNF-α.

关 键 词：痛风 虎杖痛风方 疗效 视觉模拟评分法 炎症细胞因子 

分 类 号：R259[医药卫生—中西医结合]