磁共振弥散加权成像评估血管阻滞剂对兔肝VX2瘤疗效的最优b值研究  

The Optimal b Value of Diffusion-weighted Imaging for Monitoring the Efficacy of Vascular-disrupting Agent on VX2 Tumor in Rabbit Liver

作　　者：刘灶松[1] 黄丹萍[1] 徐向东[1] 常汉征[1] 杨蕊梦[1] LIU Zao-song;HUANG Dan-ping;XU Xiang-dong;CHANG Han-zheng;YANG Rui-meng(Department of Radiology,Guangzhou First People's Hospital Affiliated to Guangzhou Medical University,Guangzhou 510180,Guangdong Province,China)

机构地区：[1]广州医科大学附属广州市第一人民医院放射科,广东广州510180

出　　处：《中国CT和MRI杂志》2021年第3期1-3,8,共4页Chinese Journal of CT and MRI

基　　金：广州市卫生计生科技一般引导项目(20181A011016)。

摘　　要：目的探讨DWI监测血管阻断剂M410治疗兔肝VX2瘤疗效的最优成像b值。方法成功建立28只肝VX2瘤模型,随机等分成2组,分别静注M410(实验组)和生理盐水(对照组)。两组于给药前、给药后14d分别进行MR平扫及DWI检查,b值分别取100、200、300、400、500、600、700、800、900 s/mm^(2)。观察肿瘤大小,T1WI、T2WI及DWI表现,测量并分析两组动物各b值下DWI图像的CNR。结果给药前实验组与对照组肿瘤平均直径分别为12.3、13.6mm,差异无统计学意义(P>0.05);给药后14d,实验组与对照组肿瘤平均直径分别为23.8、31.7mm,差异有统计学意义(P<0.05)。肿瘤TiWI表现为低信号,T2WI主要为高信号,部分内部见低信号凝固性坏死区;b值小于600s/mm^(2)时,DWI图片上肿瘤与胆囊均表现为高信号影,其中胆囊呈明亮高信号,高于肿瘤信号;当b值大于等于600s/mm^(2)时,胆囊信号明显减低,但肿瘤仍为高信号,信号改变不明显;当b值等于700s/mm^(2)时,治疗前后CNR的差别最大,差异有统计学意义(P<0.05)。结论采用DWI检测新型血管阻断剂M410对兔肝VX2瘤的疗效时,b值选取700s/mm^(2)为较为合适。Objective To explore the optimal b value of DWI for monitoring the efficacy of vascular disrupting agent to VX2 tumor in ra bbit liver.Methods 28 liver VX2 tumor models were successfully esta blished and then were randomly divided into treated and control groups.MR plain scan and DWI were performed before and 14 days after administration respectively in the two groups b values are 100,200,300,400,500,600,700,800,900 s/mm^(2).Tumor size,T1 WI,T2 WI,and DWI manifestations were observed,and CNR of DWI at each b value was measured and analyzed.Results The mean tumor diameter of the experimental group and the control group was 12.3 mm and 13.6 mm before drug administration,and the difference was not statistically significant(P>0.05).14 d after administration,the mean tumor diameter of the experimental group and the control group was 23.8 mm and31.7 mm,with statistically significant differences(P<0.05).The tumor showed a low signal on T1 WI and a high signal on T2 WI,with some areas of coagulation necrosis showed a low signal.When the b value is less than 600 s/mm^(2),both the tumor and the gallbladder showed high-signal on DWI,and the signal of the gallbladder is higher than the signal of the tumor.When the b value is greater than or equal to 600 s/m m^(2),the gallbladder signa decreased significantly,but the signal of the tumor was still high.When b value was 700 s/mm^(2),the difference of CNR was largest between before and after treatment,and the difference was statistically significant(P<0.05).Conclusion When DWI was used to monitoring the efficacy of M410 therapy on VX2 tumors of the rabbit liver,the optimal b value was700 s/mm^(2).

关 键 词：血管阻断剂 磁共振成像 扩散加权成像 VX2瘤 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.12[医药卫生—诊断学]